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Post by matt on Jul 10, 2017 8:49:50 GMT -5
2. If that works, your doctor will not want to change. That, in one sentence, is the Afrezza story. Diabetes, like most metabolic diseases, is difficult to control simply because when you administer a drug to control one symptom, it has effects on two or three other variables as well, resulting in a medical game of whack-a-mole. When a physician finds a drug, or a combination of drugs, that work for a patient, and that the patient is willing to take as prescribed, they are very reluctant to change the treatment. Regardless of whether Afrezza has benefits not available with other forms of insulin, the fact is that the other insulins work for many, many patients. Physicians practice by the "If it ain't broke, don't fix it" school of thought because experience has taught them the wisdom of that approach. Ultimately, that is the behavior that MNKD is trying to change and it is a tall order. |
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Post by rockstarrick on Jul 10, 2017 8:55:12 GMT -5
Hey CCI, Nice post and I also have to say we are in the same boat. I started investing in MNKD about 6 years ago when it was pinned at 3.00 SP for months. I started small and then after adcom I went big rode it up to over 10.00 when I was convinced it would go a lot higher. Then we partnered with Sanofi and that was our spiral down. I think some how the shorts knew Sanofi was going to sabotage Afrezza it just did not make sense how confident they were. Anyways I have been fortunate enough to be able to average down enough, where some may have been all in and may have had to sell at losses to cover unexpected expenses. I feel really bad for them, and I hope they were able to get back in . I am confident that MNKD will succeed and we are at a point when all the pieces will come together in the next few months. It's all about time money and runway and we will get it I have no worries what so ever. Just hold on and don't stress out over the short term deflated SP it's only temporary and time will prove Afrezzas success. It always seems like we are waiting for something big to raise the stock price month over month but if you think about it MNKD is just getting started only 1 year old it's all coming together. Good luck everyone. And sports I do remember the roll call. I'm still here not going anywhere;-) Who was that masked man ?? anybody get a name. 😜 |
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Post by Deleted on Jul 10, 2017 8:57:12 GMT -5
matt Except for Afrezza other forms of insulin are slowly killing the patient. I'm surprised that someone of your supposed background thinks most other forms of insulin are working.
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Post by centralcoastinvestor on Jul 10, 2017 18:21:18 GMT -5
Hi CCI, you know I've been in since 07 also. Not going anywhere:-) Afrezza has not changed. But I'm hearing that doctors minds are. Slowly. And without the awareness I thought we needed. But I'm all for all we can get! I'm so impressed with our key players! They are networking all the time. Getting more on board. Charles has such a big heart. You can't hide that. We lost Al but I do think he would be proud of our team! Hey Rick this is just like roll-call of the old days:-) Love you guys, sports I remember well the roll call on YMB. I'm still here too. What a long haul it has been. I'm down 85% or so on my investment and believe more firmly in Afrezza than ever. What a nutty stock this is. |
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Post by sayhey24 on Jul 10, 2017 20:09:47 GMT -5
2. If that works, your doctor will not want to change. That, in one sentence, is the Afrezza story. Diabetes, like most metabolic diseases, is difficult to control simply because when you administer a drug to control one symptom, it has effects on two or three other variables as well, resulting in a medical game of whack-a-mole. When a physician finds a drug, or a combination of drugs, that work for a patient, and that the patient is willing to take as prescribed, they are very reluctant to change the treatment. Regardless of whether Afrezza has benefits not available with other forms of insulin, the fact is that the other insulins work for many, many patients. Physicians practice by the "If it ain't broke, don't fix it" school of thought because experience has taught them the wisdom of that approach. Ultimately, that is the behavior that MNKD is trying to change and it is a tall order. Matt - what you describe it the real beauty of afrezza. Doctors no longer need to prescribe multiple drugs. What we know is no T2 med addresses the principle issue T2s have which is meal time sugar spikes. Today they give them metformin which does not work, then they add one or more of the other more toxic drugs. Take your pick; invokana - Kidney Damage, Ketoacidosis & Amputations; januvia - pancreatitis and pancreatic cancer; and the list goes on. I am failing to see the wisdom of this approach. It is clearly broken, its way broken as most current T2s are not even getting to 7.0 let alone 5.5 A1c. Then they loose an arm or get cancer or have a heart attack. And this "ain't broke"  Anyone who thinks the current approach is not broken is either clueless or a moron. What is currently going on is insanity. The madness needs to stop now and hopefully some of the lawsuits will help. I sure wish the FDA would make the prescribing doctors name a mandatory field on their product complaint form. It would make lawsuits against individual doctors much easier and would make them think twice about continuing to prescribe these poisons. The good news is it really does not take that long to turn things. With avandia it was a NY Times article. Sales dropped over night. A nice full page article on the dangers of these poisons now that afrezza is not only an option but actually addresses the T2 issue wouldn't hurt. |
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Post by mango on Jul 10, 2017 22:08:03 GMT -5
That, in one sentence, is the Afrezza story. Diabetes, like most metabolic diseases, is difficult to control simply because when you administer a drug to control one symptom, it has effects on two or three other variables as well, resulting in a medical game of whack-a-mole. When a physician finds a drug, or a combination of drugs, that work for a patient, and that the patient is willing to take as prescribed, they are very reluctant to change the treatment. Regardless of whether Afrezza has benefits not available with other forms of insulin, the fact is that the other insulins work for many, many patients. Physicians practice by the "If it ain't broke, don't fix it" school of thought because experience has taught them the wisdom of that approach. Ultimately, that is the behavior that MNKD is trying to change and it is a tall order. Matt - what you describe it the real beauty of afrezza. Doctors no longer need to prescribe multiple drugs. What we know is no T2 med addresses the principle issue T2s have which is meal time sugar spikes. Today they give them metformin which does not work, then they add one or more of the other more toxic drugs. Take your pick; invokana - Kidney Damage, Ketoacidosis & Amputations; januvia - pancreatitis and pancreatic cancer; and the list goes on. I am failing to see the wisdom of this approach. It is clearly broken, its way broken as most current T2s are not even getting to 7.0 let alone 5.5 A1c. Then they loose an arm or get cancer or have a heart attack. And this "ain't broke" Anyone who thinks the current approach is not broken is either clueless or a moron. What is currently going on is insanity. The madness needs to stop now and hopefully some of the lawsuits will help. I sure wish the FDA would make the prescribing doctors name a mandatory field on their product complaint form. It would make lawsuits against individual doctors much easier and would make them think twice about continuing to prescribe these poisons. The good news is it really does not take that long to turn things. With avandia it was a NY Times article. Sales dropped over night. A nice full page article on the dangers of these poisons now that afrezza is not only an option but actually addresses the T2 issue wouldn't hurt. Exactly. |
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Post by traderdennis on Jul 10, 2017 22:31:55 GMT -5
It's understandably hard to change inertia for T2s who are already on a regimen but for early and new T2s, why would anyone choose a GLP-1 shot and Metformin with health risks versus starting on Afrezza to keep their A1c down? Just asking to learn. Due to costs, insurance will never pay for ANY insulin as a first line treatment for T2 diabetes. Exercise, education, metformin, weight loss, are extremely inexpensive and can be very effective protocols for a large percentage T2's. About the worst side effect with Metformin is having to poo too many times a day. It also costs less than $5 bucks per month as a generic rx. There should be a large enough market for Afrezza as a third line treatment protocol for T2 when a patient fails at met, diet and exercise plus a second line treatment (januvia, actos, victoza or sulfanareas etc) Unfortunately MNKD has not be successful in lobbying for a treatment shift from either the American Diabetes Association, or the association of endocrinologists. |
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Post by traderdennis on Jul 10, 2017 22:35:59 GMT -5
matt Except for Afrezza other forms of insulin are slowly killing the patient. I'm surprised that someone of your supposed background thinks most other forms of insulin are working. Kastanes, Please show me an article where other forms of insulin are slowly killing patients. Thats like the anti vaccine crowd tying vaccines to autism. No proof. |
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Post by Deleted on Jul 11, 2017 6:49:16 GMT -5
matt Except for Afrezza other forms of insulin are slowly killing the patient. I'm surprised that someone of your supposed background thinks most other forms of insulin are working. Kastanes, Please show me an article where other forms of insulin are slowly killing patients. Â Thats like the anti vaccine crowd tying vaccines to autism. Â No proof. Do you not see diabetics missing appendages or limbs, on dialysis, losing eyesight or blind,...? |
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Post by silentknight on Jul 11, 2017 7:21:58 GMT -5
Kastanes, Please show me an article where other forms of insulin are slowly killing patients. Thats like the anti vaccine crowd tying vaccines to autism. No proof. Do you not see diabetics missing appendages or limbs, on dialysis, losing eyesight or blind,...? I'm not sure you can make the connection that insulins that aren't specifically Afrezza are the cause of amputations, dialysis, or many of the other symptoms or unfortunate results of diabetes. They're the result of uncontrolled blood sugar levels destroying the body from the inside out. My uncle had diabetes for the better part of his life. Before he passed away, he was on dialysis and ended up having both legs amputated but I assure you it had nothing to do with the insulins he was prescribed. This was before Afrezza, mind you, but he simply refused to properly control his disease with the tools given to him. He wouldn't inject when he needed to and he ate whatever he wanted when he wanted it. And yes, it killed him. His refusal to control his blood sugar with insulin led to the deterioration of his body, not the drugs given to him had he chose to use them. I know diabetics who live full and healthy lives on insulin that isn't Afrezza. To say that Afrezza is required to be healthy as a diabetic is factually incorrect. It may be a better treatment option, subjectively, but there are millions of people doing just fine, or well enough, without Afrezza. Just look at the weekly script numbers as proof. |
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Post by akemp3000 on Jul 11, 2017 7:32:19 GMT -5
Proof of the ineffectiveness of conventional diabetes drugs is the increasing number of diabetics. Even taking lifestyle choices into account, current options are not working sufficiently.
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Post by Deleted on Jul 11, 2017 7:36:17 GMT -5
silentknight "They're the result of uncontrolled blood sugar levels destroying the body from the inside out." And you blame uncontrolled blood sugar levels while taking other forms of insulin on???
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Post by peppy on Jul 11, 2017 7:44:18 GMT -5
It's understandably hard to change inertia for T2s who are already on a regimen but for early and new T2s, why would anyone choose a GLP-1 shot and Metformin with health risks versus starting on Afrezza to keep their A1c down? Just asking to learn. If you're asking to learn, then here are a few reasons (Answering as a T2 for 17 years. Currently well controlled (A1C 6.2) on Metformin, Forxiga and Basal & Mealtime insulin.) 1. Because after diet and exercise, Metformin is what most doctors recommend, adding a second therapy (in this case GLP-1) if necessary. 2. If that works, your doctor will not want to change. 3. Metformin is quite safe and well tolerated, despite some rather tin foil claims to the contrary 'round here. Insulin has far more health risk, regardless of administration route (hypo, weight gain, increased LDL, increased BP) than Metformin, and initiating insulin therapy can impact your ability to obtain or retain life insurance. Obviously, it's eventually necessary for many T2s, but where applicable, therapies like Metformin that increase insulin sensitivity allow the body to properly regulate blood glucose instead of the blunt tool of exogenous insulin. ok, with all of the above. additionally, the reason metformin is given. metformin mimics the phase one, that subq insulin does not give.
Afrezza is phase one and phase two. insulin.
So pharma not having afrezza, did it's best to work it. metformin is cheap.
FARXIGA safely and effectively www.accessdata.fda.gov/drugsatfda_docs/label/2014/202293s000lbl.pdf
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Post by Deleted on Jul 11, 2017 8:02:34 GMT -5
traderdennis "About the worst side effect with Metformin is having to poo too many times a day. Â It also costs less than $5 bucks per month as a generic rx." Tell that to my landlord on Metformin that requires his big toe to be amputated!
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Post by silentknight on Jul 11, 2017 8:12:50 GMT -5
silentknight "They're the result of uncontrolled blood sugar levels destroying the body from the inside out." And you blame uncontrolled blood sugar levels while taking other forms of insulin on??? What you're speaking of is completely unrelated to my example where insulin was hardly used at all, or to many others here who have demonstrated other forms of insulin to be highly effective in managing their blood glucose levels. My uncle refused to properly use the insulin prescribed to him. Had he used it properly, it likely would have prevented many of the unfortunate results that befell him and he would probably be alive today. Derek2 and others here have detailed their own control of diabetes, using Metformin and other control mechanisms, with A1C levels in the 5's and 6's. No Afrezza use at all and they're winning the battle against the disease. My point is this: Afrezza is a fantastic and highly effective tool to manage blood glucose levels when used properly. What it is NOT, is required by diabetics to ensure proper control. Doctors and patients all over the U.S. have determined that Afrezza is not necessary for them and that their current regimen is sufficient. If you try to persuade an endocrinologist that the Humalog or Novalog that he's prescribed for his/her patient is the cause of their kidney failure, foot and leg amputations, or loss of their sight, they'll probably just laugh and show you the door, not to mention pointing out that the label for those drugs doesn't jive with that either. I'm not arguing Afrezza's effectiveness. It's unparalleled when used properly. But saying that other forms of insulin are responsible for the side affects of diabetes is like saying that the antivirals used to treat HIV/AIDS are the cause of a compromised immune system. The disease does that, not the treatment. |
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