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Post by kc on Jun 9, 2014 20:34:00 GMT -5
Dr. Welcome to the board. You sound like the right type of person to educate us as we learn more about the product. Were you involved in the clinical trials with the Pfizer product? Just curious. Will you be an attendee at the ADA meeting in SF. If so would you give us feedback of any presentation MannKind might make there.
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Post by Deleted on Jun 9, 2014 20:36:32 GMT -5
I appreciate the blunt honesty. I don't mind the direct responses as they are welcome, as long as they are answering my questions. Let me give this board some background on me. Maybe this will enlighten your responses as to my asking. I am an Internal Medicine Doctor. I have been in practice for a very very very long time. I am very familiar with the company at hand, 100% more than anyone here, considering I have prescribed insulin derivatives to all my patients and I have been asked by many companies to take part in their clinical trials. What I am not familiar with and which is why I'm here is that Im new to the market. I am willing to share my insight in return for some guidance on investing regarding Pharmaceuticals. I don't like the roller coaster rides they bring, but I do see the upside. I prefer to try this out versus keep my money in mutual funds and have them stagnant. I hope this information will help you help me ..... May I ask: What knowledge do you have of Afrezza? Have you participated in any of its clinical trials? You surely have valuable background knowledge given your professional experience. But there are many similar professionals, I think, who know nothing of Afrezza, the Technosphere platform, and this company and its founder whom we so respect. Welcome to this board and thank you for your participation. GLTY, GLTA! Im afraid I don't quite understand if your asking me what my background is or what I know of the products Afrezza carries? Either way I am board certified meaning Im a professional expert. I worked 7 years of my life for extremely large corporations bigger than Afrezza, after which I decided to go on my own. I am very familiar with Afrezza, and all of its current and upcoming pipelines. What fascinates me and the reason I have come on here is to understand why this has become such a big ordeal for many. Keep in mind we have previously had a inhalation form insulin therapy. It didn't work well with our patients and we stopped prescribing it. Now its non existent. It was called Exubera. Wether this will actually function in the medical world is still debatable. I guess you can say, second times the charm? You would want to argue and say most patients prefer inhalation over needles right? Wrong. Now a days we have such tiny needles it almost becomes negligible for most patients who need insulin therapy. Keep in mind, most diabetics don't feel the same sensations such as pain like you and I do because they are less sensitized due to the nature of their disease. Furthermore, Inhalation insulin??? Really, generalized? versus injecting in your fat? You really want to wait around and see the side effects associated in a few years as you stick a insulin devise in your nostrils and dry up your concha? I think my stance is no. As an internal medicine doctor, I would not use this device, and I would argue that most of my fellow doctors at least in my hospital would not either. Granted it is an optional choice in that minute chance one patient is uninterested in needles, however I don't think that will stop me from my dislike of the inhalation form. |
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Post by Deleted on Jun 9, 2014 20:38:14 GMT -5
Dr. Welcome to the board. You sound like the right type of person to educate us as we learn more about the product. Were you involved in the clinical trials with the Pfizer product? Just curious. Will you be an attendee at the ADA meeting in SF. If so would you give us feedback of any presentation MannKind might make there. Thank you for the welcome. I have expressed my thoughts above. Please let me know if I can be any more clear about my position. With all this aside, approval is most likely eminent. Use however is debatable. |
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Post by brentie on Jun 9, 2014 20:49:30 GMT -5
May I ask: What knowledge do you have of Afrezza? Have you participated in any of its clinical trials? You surely have valuable background knowledge given your professional experience. But there are many similar professionals, I think, who know nothing of Afrezza, the Technosphere platform, and this company and its founder whom we so respect. Welcome to this board and thank you for your participation. GLTY, GLTA! Im afraid I don't quite understand if your asking me what my background is or what I know of the products Afrezza carries? Either way I am board certified meaning Im a professional expert. I worked 7 years of my life for extremely large corporations bigger than Afrezza, after which I decided to go on my own. I am very familiar with Afrezza, and all of its current and upcoming pipelines. What fascinates me and the reason I have come on here is to understand why this has become such a big ordeal for many. Keep in mind we have previously had a inhalation form insulin therapy. It didn't work well with our patients and we stopped prescribing it. Now its non existent. It was called Exubera. Wether this will actually function in the medical world is still debatable. I guess you can say, second times the charm? You would want to argue and say most patients prefer inhalation over needles right? Wrong. Now a days we have such tiny needles it almost becomes negligible for most patients who need insulin therapy. Keep in mind, most diabetics don't feel the same sensations such as pain like you and I do because they are less sensitized due to the nature of their disease. Furthermore, Inhalation insulin??? Really, generalized? versus injecting in your fat? You really want to wait around and see the side effects associated in a few years as you stick a insulin devise in your nostrils and dry up your concha? I think my stance is no. As an internal medicine doctor, I would not use this device, and I would argue that most of my fellow doctors at least in my hospital would not either. Granted it is an optional choice in that minute chance one patient is uninterested in needles, however I don't think that will stop me from my dislike of the inhalation form. You say you're very familiar with Afrezza and then you call Afrezza a corporation and say it's inhaled through your nose? Ok, Doc. |
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Post by Deleted on Jun 9, 2014 20:52:51 GMT -5
Im afraid I don't quite understand if your asking me what my background is or what I know of the products Afrezza carries? Either way I am board certified meaning Im a professional expert. I worked 7 years of my life for extremely large corporations bigger than Afrezza, after which I decided to go on my own. I am very familiar with Afrezza, and all of its current and upcoming pipelines. What fascinates me and the reason I have come on here is to understand why this has become such a big ordeal for many. Keep in mind we have previously had a inhalation form insulin therapy. It didn't work well with our patients and we stopped prescribing it. Now its non existent. It was called Exubera. Wether this will actually function in the medical world is still debatable. I guess you can say, second times the charm? You would want to argue and say most patients prefer inhalation over needles right? Wrong. Now a days we have such tiny needles it almost becomes negligible for most patients who need insulin therapy. Keep in mind, most diabetics don't feel the same sensations such as pain like you and I do because they are less sensitized due to the nature of their disease. Furthermore, Inhalation insulin??? Really, generalized? versus injecting in your fat? You really want to wait around and see the side effects associated in a few years as you stick a insulin devise in your nostrils and dry up your concha? I think my stance is no. As an internal medicine doctor, I would not use this device, and I would argue that most of my fellow doctors at least in my hospital would not either. Granted it is an optional choice in that minute chance one patient is uninterested in needles, however I don't think that will stop me from my dislike of the inhalation form. You say you're very familiar with Afrezza and then you call Afrezza a corporation and say it's inhaled through your nose? Ok, Doc. I apologize if you misunderstood me, or I did not proofread what I wrote, but my reference comes re- Exubera. The now non existent pipeline product developed by a competitor for similar use. My generalized statement is regarding any form of parenteral parameters besides SC. |
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Post by BD on Jun 9, 2014 21:05:50 GMT -5
Mankind, you went into a detailed rant about the possible ill-efects of inhaling Afrezza through your nostrils and having it "dry up your concha". A proofreading issue would be to misspell "concha". But how would even inhaling through the nostrils dry up an organ of the inner ear?
Your credibility is not increasing here, buddy.
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Post by brentie on Jun 9, 2014 21:14:53 GMT -5
" As an internal medicine doctor, I would not use this device, and I would argue that most of my fellow doctors at least in my hospital would not either." If you look at slide 14, on the site below, it would appear that you and your fellow Doctors at your hospital are a minority. afresa.blogspot.com/ |
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Post by Deleted on Jun 9, 2014 21:46:42 GMT -5
Any device inverted into a hollow organ with simple squamous cells will feel an impact regardless of what hole you stick your device BD Long term effects are not demonstrated in this test, as they are all acute forms of experimental tests. You can cause Allergies, Eczema, Psoriatic type scaling, possibly new habitation for aerobic microbes, etc. Im not attempting to defend my honor here. Im merely expressing my personal feelings. I understand some of you may not like what I say, but that doesn't take away from the fact that medicine is a thought process in which one must weigh the benefits and the risks. In this case, I don't see it beneficial. Im sorry. Remember my words. If this passes, it will also fail in the long run. |
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Post by Deleted on Jun 9, 2014 21:49:36 GMT -5
for those of you who don't understand the process:
It’s an ultrarapid-acting insulin in powder form that’s designed as a pre-meal insulin for adults with type 1 or type 2 diabetes. It’s aimed at post-meal blood sugar spikes, used with existing insulin treatment for basal coverage, so not meant as a stand-alone insulin therapy.
The powdered insulin goes into the whistle-sized inhaler called the Dreamboat, which was developed after MannKind’s first FDA round, and caused delays because the agency wanted more clinical studies comparing this new inhaler to the original.
The powder dissolves immediately when inhaled into the lungs, and the insulin’s then quickly dumped into the bloodstream to start working. Afrezza peaks within 12 to 15 minutes and is out of the system within an hour, compared to current fast-acting insulins that usually take at least 20 minutes to kick in, peak at 2-3 hours, and can stay in the system for as long as five hours.
Each single-use cartridge of Afrezza insulin would be either 3 units or a double-dose of 6 units. MannKind CFO Matt Pfeffer tells us they’re also planning 9 and 12-unit cartridges once they get initial FDA approval.
The Dreamboat is disposable, meant to be thrown away after 15 days to prevent any powder buildup inside that could clog the device. And unlike traditional insulin, you don’t have to refrigerate it.
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Post by ezrasfund on Jun 9, 2014 22:13:56 GMT -5
That is a pretty good summary of Afrezza. The question is really whether Afrezza will be widely prescribed and widely used. Millions of patients and billions of doses are big numbers. Perhaps the last binary event will be the roll out and the sales figures from the first quarters or the first year. Just ask the folks at DNDN. But if you don't want to cure cancer or control diabetes you can always just sell at the top. LOL. If any one has asked these questions, Al Mann has. He thinks MNKD will make billions of doses, and I agree.
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Post by trenddiver on Jun 9, 2014 23:52:11 GMT -5
Something doesn't make sense. You have this new member named Mankind who is whining because he lost a few dollars in the stock because of "insider selling"
Then he claims he is really an internal medicine doctor who states that he would not prescribe the Afrezza, nor would any of his colleagues, and that Afrezza will fail.
Why would anyone go long the stock if you believed it would fail? Does anyone believe this person is who he says he is? My take is that he is short the stock, or working for AF. Any money this fool says he lost, is because his short position hasn't worked out. Anyhow, it is a waste of time to engage him in conversation.
Trend
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Post by bradleysbest on Jun 10, 2014 0:19:40 GMT -5
I do not believe a word he says! If you do not believe in the product why invest?
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Post by hopetoretire on Jun 10, 2014 0:44:24 GMT -5
You say you're very familiar with Afrezza and then you call Afrezza a corporation and say it's inhaled through your nose? Ok, Doc. I apologize if you misunderstood me, or I did not proofread what I wrote, but my reference comes re- Exubera. The now non existent pipeline product developed by a competitor for similar use. My generalized statement is regarding any form of parenteral parameters besides SC. Uh.....Exubera was NOT inhaled through the nostrils either doc. Maybe you are thinking about another medicine and are on the wrong board. For sure you have your body holes mixed up. |
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Post by babaoriley on Jun 10, 2014 1:05:44 GMT -5
Really, people, could you not see through the doc from his first couple of posts (sorry, Coco)!!! He's been a doc a very, very, very long time, and is 100% more knowledgeable about the company "afrezza" than anyone else on the board - he's so old, he's forgotten how to write, how to spell, how to make sense, how to tell the difference between the nose and the mouth, how to lie convincingly, well, heck, if he remembered all that stuff he's forgotten, perhaps he would have half a brain. Give up the practice, doc, you're going to get your butt sued by your "patients." LOL!
He was devastated by the drop in price the other day, cuz he's an idiot short, trying to get out cheaply as possible, what a sorry character. Okay, if this is another Coco, then at least he needs to be outed to the AMA and have his license revoked. I believe the doc is a doctor of INTERNET medicine, and the side effects of his prescriptions are positively nauseating.
Been watching hockey and 24, or would have written this earlier, what a macaroon! Glad most have jumped on this character! Trend, loved your post!!
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Post by coco on Jun 10, 2014 1:34:08 GMT -5
Gosh, I hope I didn't sound like that and if I did, I can see why all of you jumped on me. This guy is totally not one of us. He is a short, even I can see though his BS. Let's try not to be distracted by posters like this. We know what we have and have to believe in the science and the company. We are stronger than to be fooled by this posser.  . Coco |
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. Coco