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Post by mango on Sept 24, 2017 18:16:08 GMT -5
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Post by liane on Sept 24, 2017 18:38:25 GMT -5
Linky doesn't work.
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Post by mango on Sept 24, 2017 18:46:46 GMT -5
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Post by mango on Nov 22, 2023 14:51:44 GMT -5
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Post by porkini on Nov 22, 2023 16:03:07 GMT -5
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Post by peppy on Nov 27, 2023 10:12:23 GMT -5
Porkini, you are an internet genius. Skimming it. "β-Cell Dysfunction and Death Although controversy exists regarding whether insulin resistance or impaired insulin secretion constitutes the primary defect in type 2 diabetes, current evidence supports β-cell function as the initial defect. Individuals with type 2 diabetes experience a gradual decline in insulin secretion that results from impairment of function and ultimately the death of pancreatic β-cells.47 Individuals with type 2 diabetes have a progressive deterioration in β-cell function and mass and a pancreatic islet cell function of about 50% of normal at the time of diagnosis.48 Two changes in β-cells contribute to the defect in insulin secretion characteristic of type 2 diabetes: a reduction in insulin secretion in response to glucose and decreased β-cell mass secondary to increased apoptosis of these cells.47 Several factors, including glucotoxicity, lipotoxicity, and the effects of pro-inflammatory cytokines, are believed to contribute to the secretory deficit and abnormal apoptosis of β-cells.47,48" |
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Post by peppy on Nov 27, 2023 10:36:48 GMT -5
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