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Post by robbmo on Sept 29, 2017 13:55:48 GMT -5
One users comment about fiasp: integrateddiabetes.com/review-of-fiasp-insulin-and-how-it-compares-with-other-fast-insulins/Thanks for the review. I have switched but I am only three weeks in.
As suggested post meal spikes are smaller and have become blips on meals of less than 30g CHO. For bigger meals it is a lot less predictable.
It stings when delivered. I tried extending to 15 min but that just prolonged the stinginess.
Cannula sited need changing more often, now diong on his daily rather than every two days
I have reduced the timing before I deliver before meals but reading your review I shall still look at these
It is a lot better when eating out and I need to wait until the food arrives to deliver. It comes down more quickly than before
As said correction work more quickly.
I have decided to give it a proper try and do at least three months. The benefits need to outweigh the stinging in delivery.
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Post by peppy on Sept 29, 2017 14:00:08 GMT -5
that stinging is cell tissue disruption.
When did we start to believe subq was a good delivery system?
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Post by robbmo on Sept 29, 2017 14:02:27 GMT -5
that stinging is cell tissue disruption. When did we start to believe subq was a good delivery system? Lol, is that burning sensation an STD or FIASP. :-) |
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Post by mango on Sept 29, 2017 14:07:00 GMT -5
that stinging is cell tissue disruption. When did we start to believe subq was a good delivery system? Life is natural. Breathe. |
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Post by agedhippie on Sept 29, 2017 15:07:33 GMT -5
that stinging is cell tissue disruption. When did we start to believe subq was a good delivery system? That happens. Move the site and it will stop stinging. Sometimes you are too close to a nerve ending. (Yes I know this isn't a problem with inhaled insulin  ) |
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Post by mytakeonit on Sept 29, 2017 15:15:48 GMT -5
Where is majorwood? He would say ... "Tough it out cry baby! Take your shot!"
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Post by peppy on Sept 29, 2017 15:18:28 GMT -5
that stinging is cell tissue disruption. When did we start to believe subq was a good delivery system? That happens. Move the site and it will stop stinging. Sometimes you are too close to a nerve ending. (Yes I know this isn't a problem with inhaled insulin ) it is all the additives aged.
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Post by agedhippie on Sept 29, 2017 15:21:05 GMT -5
Another response from that thread:
My experience of Fiasp is rather different from what you’ve written above. I (and quite a few others) have found that we can take it immediately prior to eating and experience very minimal post prandial rises in blood glucose, indeed, I have tested in with a fairly boring white bread and jam meal, with an immediate pre-prandial dose, and found no rise in glucose levels.A fair number of people have found that bolusing as you would with normal fast acting insulins results in hypos very soon after eating.
Since the onset is slower you bolus at the start of a meal rather than 10 minutes in. There seems to be the same minimal rise you get with Afrezza and hypo is you bolus early. A jam sandwich is about 45g of carbs and fast acting (both white bread and jam are high GI foods) so to get no rise is very good.
On the speculation side... I am beginning to wonder if the important thing is hitting a particular sweet spot. With Afrezza it seems to be 10 minutes in, with FIasp it seems to be at first bite, with Novolog/Humalog who knows.
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Post by peppy on Sept 29, 2017 15:24:05 GMT -5
sounds good, and the other side, the length?
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Post by mango on Sept 29, 2017 15:35:32 GMT -5
Endogenous prandial insulin responds to the ingestion of a meal by a rapid release of insulin from the beta cells, this is called the early phase insulin response. T1D and T2D no longer have the early phase insulin response so it must come from an exogenous insulin that physiologically mimics endogenous prandial insulin secretion of an healthy non-diabetic pancreas. The peak serum insulin concentration must be reached within the natural physiological time-frame. This is required in order to restore postprandial glucose homeostasis. Only Afrezza can do that.  |
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Post by agedhippie on Sept 29, 2017 15:38:34 GMT -5
sounds good, and the other side, the length? Lots of people are keen on the quick out and I find myself conflicted. For corrections I really like the idea of fast clearance because I just want my levels down so I want it over with and a short tail. For meals though I would rather have an insulin with long tail because I don't want to take a follow up dose. I think it's why in the blogs and boards you see people using Afrezza for corrections and RAA for meals. |
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Post by dreamboatcruise on Sept 29, 2017 15:47:28 GMT -5
sounds good, and the other side, the length? Lots of people are keen on the quick out and I find myself conflicted. For corrections I really like the idea of fast clearance because I just want my levels down so I want it over with and a short tail. For meals though I would rather have an insulin with long tail because I don't want to take a follow up dose. I think it's why in the blogs and boards you see people using Afrezza for corrections and RAA for meals. Presumably you don't have problems with delayed hypos? Do you try to eat meals that roughly match pd profile of the RAA you use? |
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Post by agedhippie on Sept 29, 2017 15:48:42 GMT -5
Endogenous prandial insulin responds to the ingestion of a meal by a rapid release of insulin from the beta cells, this is called the early phase insulin response. T1D and T2D no longer have the early phase insulin response so it must come from an exogenous insulin that physiologically mimics endogenous prandial insulin secretion of an healthy non-diabetic pancreas. The peak serum insulin concentration must be reached within the natural physiological time-frame. This is required in order to restore postprandial glucose homeostasis. Only Afrezza can do that. My focus is on the outcome. If FIasp gives me that outcome why would I care about physiological matches? |
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Post by agedhippie on Sept 29, 2017 16:17:18 GMT -5
Lots of people are keen on the quick out and I find myself conflicted. For corrections I really like the idea of fast clearance because I just want my levels down so I want it over with and a short tail. For meals though I would rather have an insulin with long tail because I don't want to take a follow up dose. I think it's why in the blogs and boards you see people using Afrezza for corrections and RAA for meals. Presumably you don't have problems with delayed hypos? Do you try to eat meals that roughly match pd profile of the RAA you use? I rarely have problems with delayed hypos and where I do it's usually because I end up eating significantly less than I bolused for. There is little you can do about that that with any insulin. Otherwise delayed hypos are usually from stacking insulin which has a simple fix - just don't do it More seriously you should deduct your insulin onboard when you dose, it's easy to do but people often don't bother and usually it doesn't matter but occasionally.... |
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Post by mango on Sept 29, 2017 17:12:47 GMT -5
Endogenous prandial insulin responds to the ingestion of a meal by a rapid release of insulin from the beta cells, this is called the early phase insulin response. T1D and T2D no longer have the early phase insulin response so it must come from an exogenous insulin that physiologically mimics endogenous prandial insulin secretion of an healthy non-diabetic pancreas. The peak serum insulin concentration must be reached within the natural physiological time-frame. This is required in order to restore postprandial glucose homeostasis. Only Afrezza can do that. My focus is on the outcome. If FIasp gives me that outcome why would I care about physiological matches? It's your life and your body and you can do whatever you want with it. The early phase insulin response is a critical component for controlling PPG. Restoring postprandial glucose homeostasis puts the body back into balance. The consequences of using an insulin product that physiologically matches prandial insulin secretion is restoring postprandial glucose homeostasis and avoidance of acute and long-term health complications associated with loss of the early phase insulin response.     |
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