|
|
Post by digger on Jan 30, 2018 23:13:10 GMT -5
|
|
|
|
Post by dreamboatcruise on Jan 31, 2018 2:58:12 GMT -5
I am intrigued by how much their PRINT technology might cut into TS pipeline. Can they control particle size as well or better than TS?
|
|
|
|
Post by mango on Jan 31, 2018 3:25:01 GMT -5
What I see here is a crappy inhaler, too many inhalations per capsule, too many capsules (and inhalations) for doses 100mcg-150mcg, and nanotechnology. What MannKind will hopefully have going for them is a single inhalation with a single cartridge for the highest dose, better exposure and a better AE report (zero painful respirations)   |
|
|
|
Post by dreamboatcruise on Jan 31, 2018 3:49:04 GMT -5
What I see here is a crappy inhaler, too many inhalations per capsule, too many capsules (and inhalations) for doses 100mcg-150mcg, and nanotechnology. Seems like the poster presentation I see just says two inhalations with one capsule for up to 150mcg... are you seeing something different? You really think needing to inhale twice is a big deal? If you need more than 12u of insulin with Afrezza you need to not only inhale twice, you need to reload... surely taking two breaths isn't a big deal. Do you know whether MNKD's formulation will do 150mcg in one breath/cartridge? |
|
|
|
Post by mango on Jan 31, 2018 4:03:35 GMT -5
What I see here is a crappy inhaler, too many inhalations per capsule, too many capsules (and inhalations) for doses 100mcg-150mcg, and nanotechnology. Seems like the poster presentation I see just says two inhalations with one capsule for up to 150mcg... are you seeing something different? You really think needing to inhale twice is a big deal? If you need more than 12u of insulin with Afrezza you need to not only inhale twice, you need to reload... surely taking two breaths isn't a big deal. Do you know whether MNKD's formulation will do 150mcg in one breath/cartridge? It's 2 inhalations per capsule. 100mcg, 125mcg, and 150mcg all require 2 capsules. That is 4 inhalations and each one has a 10 second breath hold recommended with it using an inhaler that has already shown to not be comfortable per the AEs, and these people already have a hard enough time with their lungs so yeah I think it's a big deal. People that take Afrezza also have their lung function checked before and during using it so inhaling 2 times for 2 cartridges with a reusable inhaler than requires zero cleaning isn't exactly a treatment burden. You also run the risk of inhaling pieces of the capsule with these types of inhalers. It's better than what is currently available I'll give it that. Can it be better? Yeah, and that's where MannKind comes in. I think they will be able to do 150mcg in one cartridge. No idea for sure though  |
|
|
|
Post by dreamboatcruise on Jan 31, 2018 4:17:26 GMT -5
Seems like the poster presentation I see just says two inhalations with one capsule for up to 150mcg... are you seeing something different? You really think needing to inhale twice is a big deal? If you need more than 12u of insulin with Afrezza you need to not only inhale twice, you need to reload... surely taking two breaths isn't a big deal. Do you know whether MNKD's formulation will do 150mcg in one breath/cartridge? It's 2 inhalations per capsule. 100mcg, 125mcg, and 150mcg all require 2 capsules. That is 4 inhalations and each one has a 10 second breath hold recommended with it using an inhaler that has already shown to not be comfortable per the AEs, and these people already have a hard enough time with their lungs so yeah I think it's a big deal. People that take Afrezza also have their lung function checked before and during using it so inhaling 2 times for 2 cartridges with a reusable inhaler than requires zero cleaning isn't exactly a treatment burden. You also run the risk of inhaling pieces of the capsule with these types of inhalers. It's better than what is currently available I'll give it that. Can it be better? Yeah, and that's where MannKind comes in. I think they will be able to do 150mcg in one cartridge. No idea for sure though In the grand scheme of things whether one inhales once or twice is probably not a big deal. The difference between RAA pk/pd and Afrezza is a big deal. Not saying there isn't any advantage to MNKDs potential Trep formulation, but I'm unconvinced by your argument. |
|
|
|
Post by peppy on Jan 31, 2018 4:19:41 GMT -5
I see more males over 40 with pulmonary hypertension in the future.
|
|
|
|
Post by dreamboatcruise on Jan 31, 2018 4:32:37 GMT -5
I see more males over 40 with pulmonary hypertension in the future. With great marketing I suppose. But Trep isn't going to make the old young  |
|
|
|
Post by peppy on Jan 31, 2018 7:50:03 GMT -5
I see more males over 40 with pulmonary hypertension in the future. With great marketing I suppose. But Trep isn't going to make the old young do you live in the same world I live in? A Stormy Night ? |
|
|
|
Post by digger on Jan 31, 2018 11:00:22 GMT -5
Seems like the poster presentation I see just says two inhalations with one capsule for up to 150mcg... are you seeing something different? You really think needing to inhale twice is a big deal? If you need more than 12u of insulin with Afrezza you need to not only inhale twice, you need to reload... surely taking two breaths isn't a big deal. Do you know whether MNKD's formulation will do 150mcg in one breath/cartridge? It's 2 inhalations per capsule. 100mcg, 125mcg, and 150mcg all require 2 capsules. That is 4 inhalations and each one has a 10 second breath hold recommended with it using an inhaler that has already shown to not be comfortable per the AEs, and these people already have a hard enough time with their lungs so yeah I think it's a big deal. People that take Afrezza also have their lung function checked before and during using it so inhaling 2 times for 2 cartridges with a reusable inhaler than requires zero cleaning isn't exactly a treatment burden. You also run the risk of inhaling pieces of the capsule with these types of inhalers. It's better than what is currently available I'll give it that. Can it be better? Yeah, and that's where MannKind comes in. I think they will be able to do 150mcg in one cartridge. No idea for sure though Yes, but the poster points out also regarding the 150 mcg dose: "This is an emitted dose ~50% higher than Tyvaso® maximum tolerated dose in healthy volunteers (84 mcg - Nelsen 2010)." In other words, the average patient likely wouldn't require more than a 75 mcg dose at a time. |
|
|
|
Post by mango on Jan 31, 2018 15:49:46 GMT -5
It's 2 inhalations per capsule. 100mcg, 125mcg, and 150mcg all require 2 capsules. That is 4 inhalations and each one has a 10 second breath hold recommended with it using an inhaler that has already shown to not be comfortable per the AEs, and these people already have a hard enough time with their lungs so yeah I think it's a big deal. People that take Afrezza also have their lung function checked before and during using it so inhaling 2 times for 2 cartridges with a reusable inhaler than requires zero cleaning isn't exactly a treatment burden. You also run the risk of inhaling pieces of the capsule with these types of inhalers. It's better than what is currently available I'll give it that. Can it be better? Yeah, and that's where MannKind comes in. I think they will be able to do 150mcg in one cartridge. No idea for sure though Yes, but the poster points out also regarding the 150 mcg dose: "This is an emitted dose ~50% higher than Tyvaso® maximum tolerated dose in healthy volunteers (84 mcg - Nelsen 2010)." In other words, the average patient likely wouldn't require more than a 75 mcg dose at a time. Patients titrate up w/ Tyvaso and their target maintance dose is 54 mcg 4 times a day. That's 216 mcg total. They start out with 18 mcg. Tolerability and side effects. Can people dose more and less frequently with fewer side effects with MannKind's? We'll see. |
|
