Joslin Diabetes Center discovery

[uvula]

Researchers from Boston’s Joslin Diabetes Center have discovered four viruses usually found in fish with the ability to create insulin-like hormones. The discovery of these viral insulin species could suggest that micro-organisms have an impact on the development of diabetes, as well as other conditions, such as autoimmune diseases and some cancers.


futurism.com/viral-insulin-fish-diabetes-cancer/

[uvula]

Same info directly from Joslin. www.joslin.org/news/virus-can-produce-insulin-like-hormones-active-on-human-cells.html

[peppy]

Mar 1, 2018 8:38:18 GMT -5 uvula said:

Researchers from Boston’s Joslin Diabetes Center have discovered four viruses usually found in fish with the ability to create insulin-like hormones. The discovery of these viral insulin species could suggest that micro-organisms have an impact on the development of diabetes, as well as other conditions, such as autoimmune diseases and some cancers.


futurism.com/viral-insulin-fish-diabetes-cancer/

"I used to jokingly say to my managed care colleagues that anyone of us can have a heart attack or stroke without prior authorization, but couldn’t get the therapies needed to prevent that heart attack or stroke." David Kendall, MD.

[dreamboatcruise]

One of the interesting things for me were the statements basically saying... they might cause auto-immune problems, or they might prevent them and they might exacerbate insulin resistance or they might mitigate it... and of course the unsaid "or they might do neither".

With something as complicated as human physiology (especially in areas as complex as endocrinology or immunology), often one can come up with theoretical mechanisms of action that might cause some particular result, but as this shows, there are often other theoretical mechanisms of action that might be just as plausible that could result in very different outcomes. Hence clinical trials in humans are the thing clinicians look for rather than merely well reasoned theoretical arguments.

[uvula]

DBC has a great point. It will take years and billions of $$$ to research this stuff. I don't think any private company would be willing to do this.

[sayhey24]

Mar 1, 2018 15:10:25 GMT -5 dreamboatcruise said:

One of the interesting things for me were the statements basically saying... they might cause auto-immune problems, or they might prevent them and they might exacerbate insulin resistance or they might mitigate it... and of course the unsaid "or they might do neither".

With something as complicated as human physiology (especially in areas as complex as endocrinology or immunology), often one can come up with theoretical mechanisms of action that might cause some particular result, but as this shows, there are often other theoretical mechanisms of action that might be just as plausible that could result in very different outcomes. Hence clinical trials in humans are the thing clinicians look for rather than merely well reasoned theoretical arguments.

DBC - I found it interesting that we recently had a discussion about what I termed the "pancreatic flu" as the root cause of T2.  What I had not considered was the same "flu" would not only kill the beta cells but simultaneously attach to the insulin receptors causing increased insulin resistance.  These guys could be on to something.

[peppy]

Mar 1, 2018 21:02:08 GMT -5 sayhey24 said:

Mar 1, 2018 15:10:25 GMT -5 dreamboatcruise said:

One of the interesting things for me were the statements basically saying... they might cause auto-immune problems, or they might prevent them and they might exacerbate insulin resistance or they might mitigate it... and of course the unsaid "or they might do neither".

With something as complicated as human physiology (especially in areas as complex as endocrinology or immunology), often one can come up with theoretical mechanisms of action that might cause some particular result, but as this shows, there are often other theoretical mechanisms of action that might be just as plausible that could result in very different outcomes. Hence clinical trials in humans are the thing clinicians look for rather than merely well reasoned theoretical arguments.

DBC - I found it interesting that we recently had a discussion about what I termed the "pancreatic flu" as the root cause of T2.  What I had not considered was the same "flu" would not only kill the beta cells but simultaneously attach to the insulin receptors causing increased insulin resistance.  These guys could be on to something.

The pancreatic fluke,
The pancreatic fluke Eurytrema pancreaticum is one of the most common flukes in the pancreas and bile ducts of ruminants[1].
www.youtube.com/watch?v=blnhMmbGpG4&t=2s
the 4 min mark. (watch from the beginning. It is interesting.)