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Post by peppy on Feb 27, 2023 17:12:17 GMT -5
Some of the comments sound like big babies to me.
MNKD is up trending.
The $COMPQ, the $SPX, the $INDU are downtrending. and not a tiny little downtrend, a years worth of downtrend.
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Post by peppy on Feb 27, 2023 16:05:59 GMT -5
MNKD volume at the half day of trade, (574,094 shares traded in the hour and 15min.) 2,115,816 5.47+0.06 (+1.02%) added, volume at 2 hours of trade, 1,541,722 Avg. Volume 3,859,124 $5.68. +0.27 (+4.99%) MNKD Nasdaq real time volume, 4,587,487 shares. MNKD Nasdaq summary volume, 4,540,263 Avg. Volume 3,859,124
$5.38. -0.03. (-0.55%) MNKD Daily, schrts.co/Xffgfmqh$COMPQ Daily, schrts.co/QvuHvYMf |
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Post by peppy on Feb 27, 2023 12:48:30 GMT -5
MNKD volume at the half day of trade, (574,094 shares traded in the hour and 15min.)
2,115,816
5.47+0.06 (+1.02%)
added, volume at 2 hours of trade,
1,541,722
Avg. Volume 3,859,124
$5.68. +0.27 (+4.99%)
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Post by peppy on Feb 27, 2023 10:38:43 GMT -5
ok, weehaw, at nauseam, charts pretty to see. MNKD weekly, schrts.co/auddfMgBMNKD Monthly working through the 100 month ma. schrts.co/fpUYjCSxadded volume at 1 and 1/2 hours of trade, real time, 1,271,850 summary, 1,299,602 $5.68+0.27 (+4.99%) The nasdaq testing 11,500, the DOW l 33,000, the $SPX testing 4,000. MNKD still trading close to 300,000 shares on the half hour. MNKD still holding new 52 week high. The second trading day after the quarterly earning call, price behavior is good. the pattern looks good. added, volume at 2 hours of trade, 1,541,722 Avg. Volume 3,859,124 $5.68. +0.27 (+4.99%) |
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Post by peppy on Feb 27, 2023 10:31:30 GMT -5
MND volume at 30 mins of trade is large for MNKD. real time, 486,429 shares summary, 487,388 Avg. Volume 3,859,124 $5.60. +0.19 (+3.51%) $5.67 will be a new 52 week high. added, MNKD is there. www.wsj.com/market-data/stocks/newfiftytwoweekhighsandlows$5.90 point of break out. New 52 week high 5.67+0.26 (+4.80%) As of 10:11AM EST. Market open. in 41 mins of trade. volume, 814,913 MNKD volume at 1 hour of trade, real time, 1,023,784 summary, 1,023,899 Avg. Volume 3,859,124 5.70+0.29 (+5.36%) As of 10:29AM EST. Market open. $5.72 hit. finance.yahoo.com/quote/MNKD?p=MNKDAdditionally MNKD share price is moving through the 100 MONTH moving average. MONTH www.nasdaq.com/market-activity/stocks/mnkd/real-timeI do not recall MNKD trading over 1 million in the first hour. I know it did in 2015 after approval and Sanofi. |
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Post by peppy on Feb 27, 2023 10:01:51 GMT -5
MND volume at 30 mins of trade is large for MNKD. real time, 486,429 shares summary, 487,388 Avg. Volume 3,859,124 $5.60. +0.19 (+3.51%) $5.67 will be a new 52 week high. added, MNKD is there. www.wsj.com/market-data/stocks/newfiftytwoweekhighsandlows$5.90 point of break out. New 52 week high 5.67+0.26 (+4.80%) As of 10:11AM EST. Market open. in 41 mins of trade. volume, 814,913 |
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Post by peppy on Feb 25, 2023 20:12:30 GMT -5
Fast-acting insulin ( Humalog) starts working within 15 minutes after injection, peaks in about 1 to 2 hours after injection, and lasts between 2 to 4 hours after injection. www.humalog.com/fast-acting-mealtime-insulinInsulin aspart ( Novolog) has an onset of 10 to 20 minutes and a peak time of 40 to 50 minutes. The duration of insulin aspart is 3 to 5 hours. canadianinsulin.com/articles/insulin-aspart-onset-peak-time-duration-action-side-effects/Insulin lispro differs from human insulin by the substitution of proline with lysine in position 28 and lysine with proline in position 29 of the B chain; insulin aspart differs from human insulin by a single substitution of proline with aspartic acid in position B28. agedhippie , big difference in peak times? or Pharmacodynamics Studies in normal volunteers and patients with diabetes demonstrated that subcutaneous administration of NovoLog has a more rapid onset of action than regular human insulin. In a 6-hour study in patients with Type 1 diabetes (n=22), the maximum glucose-lowering effect of NovoLog occurred between 1 and 3 hours after subcutaneous injection (see Figure 3). The duration of action for NovoLog is 3 to 5 hours www.accessdata.fda.gov/drugsatfda_docs/label/2005/20986s032lbl.pdf |
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Post by peppy on Feb 25, 2023 19:37:49 GMT -5
Fast-acting insulin ( Humalog) starts working within 15 minutes after injection, peaks in about 1 to 2 hours after injection, and lasts between 2 to 4 hours after injection. www.humalog.com/fast-acting-mealtime-insulinInsulin aspart ( Novolog) has an onset of 10 to 20 minutes and a peak time of 40 to 50 minutes. The duration of insulin aspart is 3 to 5 hours. canadianinsulin.com/articles/insulin-aspart-onset-peak-time-duration-action-side-effects/Insulin lispro differs from human insulin by the substitution of proline with lysine in position 28 and lysine with proline in position 29 of the B chain; insulin aspart differs from human insulin by a single substitution of proline with aspartic acid in position B28. agedhippie, big difference in peak times? |
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Post by peppy on Feb 25, 2023 16:32:44 GMT -5
Here comes your favorite wet blanket  I have no idea why anyone thinks this is a surprise unless they don't understand how AID pumps work. TL;DR You have bolused for the meal and hence have insulin onboard so the pump (correctly) will not adjust the basal rate. Therefore the result should be the same as for STAT - you are looking at RAA bolus vs. Afrezza and already STAT told us what that outcome will be. Longer version You are looking at a maximum of 120 minutes. We already know from the STAT results that what the 120 minute readings will be:  Why does anyone think this is going to different for an AID pump over Tresiba? The AID pump provides basal via RAA, and because the pump knows you have bolused it know there is insulin onboard to cover the food so it's not going to change the basal RAA and you get a flat basal curve, just like you would with Tresiba. This is a definitely not going to move the endos. The large scale ABC trial will be interesting, especially the Afrezza with food and pump the rest of the time arm. Here is the original STAT study chart. mnkd.proboards.com/thread/10239/dr-kendall-presents-stat-study1Scroll down |
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Post by peppy on Feb 25, 2023 15:49:00 GMT -5
Correct - Mike said they were holding the main data for ADA2023. This is only afrezza with AID and AID without afrezza. This does not include Tresiba. What we can say is the graphs they presented are nothing like the graph you referred to earlier in the thread from STAT. I guess I can also say it makes sense Lance is now working with MNKD. There is no way he can write an alogorithm to beat this. ... I realized I didn't answer the first part of that post! The graph curves are the same except that they are cut off after 2 hours unlike the STAT graph which ran for five hours. This was using a standardized meal under lab conditions, STAT was real world so the meal were wherever and anything but standardized You attach way to much importance to Nudge BG performing a consultancy engagement with Mannkind. If you hire an industry expert consultant that doesn't mean they are working with you beyond that engagement (or I am working for a ton of companies!) The stat showed how fearful type ones were to take a follow dose. You know afrezza needs the one hour follow up dose. |
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Post by peppy on Feb 25, 2023 15:46:31 GMT -5
You use a pen. You have control of how much insulin you have on board when. It would seem you prefer control of your own insulin determination. Both the pump and I agree - if I have enough insulin onboard to cover the meal I should not take more to chase the curve. TBH though, sometimes I will stack because I know that before my levels drop badly I will have eaten again - think of it as long range pre-bolusing! But just to chase the curve? No. well you have 1 and 1/2 to 2 hours, so..... yep. Peak serum concentrations of insulin lispro occur 30 to 90 minutes after subcutaneous administration. www.aafp.org/pubs/afp/issues/1998/0115/p279.html |
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Post by peppy on Feb 25, 2023 13:40:30 GMT -5
... At the 2hr mark there is a really significant difference between TI+AID vs AID alone - about 50mg/dl. Thats surprising to me that AID still had not caught up at 2hrs. I think the difference between this and Dave Kendall's STAT was the dosing and of course help of the AID after 90 minutes. For this they based the afrezza dosing on doubling the RAA dose and rounding down. ... The curve for RAA is well established so the results from the AID are exactly as expected. Since the pump has delivered insulin for the food when the person ate and that insulin is still active the pump is simply maintaining the basal. It's quite possible for the pump to issue more insulin and chase the curve, but now you have all the insulin you need plus an extra dose - that's the sort of stacking that causes hypos as they now would have far to much insulin in your system.You use a pen. You have control of how much insulin you have on board when. It would seem you prefer control of your own insulin determination. |
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Post by peppy on Feb 24, 2023 16:11:21 GMT -5
MNKD Nasdaq real time volume, 4,462,081 shares. MNKD Nasdaq summary volume, 4,111,181 Avg. Volume 3,814,927 $5.41. +0.19 (+3.64%) MNKD charts. (click on any chart on this thread, the charts update) Daily schrts.co/aGZHBQQpWeekly, schrts.co/PjrUMviqMonthly. schrts.co/PuYEPCfY$COMPQ daily schrts.co/ENKKMHXT |
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Post by peppy on Feb 24, 2023 15:08:57 GMT -5
How many APIs has MNKD taken through Phase 1? Technosphere Insulin Treprostinil Technosphere Clofazimine nebulizer and what else? epinephrine and perhaps Sumatriptan? |
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Post by peppy on Feb 24, 2023 13:12:45 GMT -5
At five mins of trade, MNKD volume is, 236,927 Avg. Volume 3,814,927 5.45+0.23 (+4.41%) As of 09:35AM EST. Market open. $5.67 will take out the highs made last week. ridem Couldn't find any news for the up trend. wrote, Analysis link on Yahoo now shows 2024 numbers. Average estimate among analysts for 2024 is a $0.19 per share profit. The 2024 high estimate calls for $0.38 per share. Nice to finally see positive numbers coming our way. |
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