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Post by porkini on Aug 24, 2021 18:40:55 GMT -5
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Post by lazyb767 on Oct 6, 2021 0:10:11 GMT -5
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Post by lazyb767 on Oct 6, 2021 0:12:48 GMT -5
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Post by Clement on Oct 6, 2021 7:01:20 GMT -5
"As of September 15th, there was short interest totalling 2,470,000 shares, a decline of 23.8% from the August 31st total of 3,240,000 shares. Approximately 5.6% of the company's shares are short sold." |
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Post by peppy on Oct 6, 2021 12:20:50 GMT -5
UTHR has gone positive on the day. MNKD leading.....  Though day in Pharma and biotech.  |
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Post by boca1girl on Oct 12, 2021 12:19:30 GMT -5
Any interest in buying UTHR today? It’s been weak leading into the FDA announcement.
I am going to put in a small buy order, GTC, at $185 and see what happens between now and Friday. Options seem too expensive and are all short term.
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Post by wyattdog on Oct 20, 2021 9:53:06 GMT -5
U.S. surgeons successfully test pig kidney transplant in human patient By Nancy Lapid
NEW YORK (Reuters) - For the first time, a pig kidney has been transplanted into a human without triggering immediate rejection by the recipient's immune system, a potentially major advance that could eventually help alleviate a dire shortage of human organs for transplant.
The procedure done at NYU Langone Health in New York City involved use of a pig whose genes had been altered so that its tissues no longer contained a molecule known to trigger almost immediate rejection.
The recipient was a brain-dead patient with signs of kidney dysfunction whose family consented to the experiment before she was due to be taken off of life support, researchers told Reuters.
For three days, the new kidney was attached to her blood vessels and maintained outside her body, giving researchers access to it. Test results of the transplanted kidney's function "looked pretty normal," said transplant surgeon Dr. Robert Montgomery, who led the study.
The kidney made "the amount of urine that you would expect" from a transplanted human kidney, he said, and there was no evidence of the vigorous, early rejection seen when unmodified pig kidneys are transplanted into non-human primates.
The recipient's abnormal creatinine level - an indicator of poor kidney function - returned to normal after the transplant, Montgomery said.
In the United States, nearly 107,000 people are presently waiting for organ transplants, including more than 90,000 awaiting a kidney, according to the United Network for Organ Sharing. Wait times for a kidney average three-to-five years.
Researchers have been working for decades on the possibility of using animal organs for transplants, but have been stymied over how to prevent immediate rejection by the human body.
Montgomery's team theorized that knocking out the pig gene for a carbohydrate that triggers rejection - a sugar molecule, or glycan, called alpha-gal - would prevent the problem. The genetically altered pig, dubbed GalSafe, was developed by United Therapeutics Corp's Revivicor unit. It was approved by the U.S. Food and Drug Administration in December 2020, for use as food for people with a meat allergy and as a potential source of human therapeutics.
Medical products developed from the pigs would still require specific FDA approval before being used in humans, the agency said.
Other researchers are considering whether GalSafe pigs can be sources of everything from heart valves to skin grafts for human patients.
The NYU kidney transplant experiment should pave the way for trials in patients with end-stage kidney failure, possibly in the next year or two, said Montgomery, himself a heart transplant recipient. Those trials might test the approach as a short-term solution for critically ill patients until a human kidney becomes available, or as a permanent graft.
The current experiment involved a single transplant, and the kidney was left in place for only three days, so any future trials are likely to uncover new barriers that will need to be overcome, Montgomery said. Participants would probably be patients with low odds of receiving a human kidney and a poor prognosis on dialysis.
"For a lot of those people, the mortality rate is as high as it is for some cancers, and we don't think twice about using new drugs and doing new trials (in cancer patients) when it might give them a couple of months more of life," Montgomery said.
The researchers worked with medical ethicists, legal and religious experts to vet the concept before asking a family for temporary access to a brain-dead patient, Montgomery said.
(Reporting by Nancy Lapid; Editing by Michele Gershberg and Bill Berkrot)
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Post by uvula on Oct 20, 2021 11:00:23 GMT -5
Wow. I heard about the pig but had no idea uthr was involved. Quite a bit different than PAH.
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Post by mnkdfann on Oct 20, 2021 14:13:22 GMT -5
Montgomery's team theorized that knocking out the pig gene for a carbohydrate that triggers rejection - a sugar molecule, or glycan, called alpha-gal - would prevent the problem. The genetically altered pig, dubbed GalSafe, was developed by United Therapeutics Corp's Revivicor unit. Revivicor? Sounds ominous. Reminds me of what is described in RoboCop and Universal Soldier, and like movies. |
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Post by boca1girl on Oct 20, 2021 14:29:18 GMT -5
Wow. I heard about the pig but had no idea uthr was involved. Quite a bit different than PAH. They are also working on lung transplants. But I remember reading that they are trying to grow lungs in the lab. The pig experimentation maybe a stepping stone to lab grown organs. They will probably try a similar experiment with pig lungs. |
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Post by lazyb767 on Oct 21, 2021 0:37:49 GMT -5
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Post by wyattdog on Oct 21, 2021 12:07:48 GMT -5
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Post by peppy on Nov 3, 2021 9:46:45 GMT -5
UTHR IS PUSHING AND SO IS MNKD opps caps. UTHR has been in a 7 month consolidation at highs as well as MNKD.  |
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Post by lennymnkd on Jan 11, 2022 6:57:19 GMT -5
Little premature taken down that uthr after hours post , it was the pig heart … 🤔hmmm
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Post by peppy on Jan 11, 2022 9:44:54 GMT -5
Little premature taken down that uthr after hours post , it was the pig heart … 🤔hmmm UTHR 207.80+8.56 (+4.30%) As of 09:40AM EST. Market open. I didn't see any news on Yahoo, however, price wise, UTHR gapped open, the gap has held and price has moved up. I heard a news mini moment on the pig heart, the heart had been for lack of a better term, humanized at some level, as the rejection is anticipated to be less. Any connection with UTHR? |
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