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Post by agedhippie on Apr 27, 2021 14:23:24 GMT -5
Now you are making me blush  TBH my interest in Mannkind is chiefly Afrezza. Most of the focus these days is UTHR and that isn't really of interest to me since happily I don't have PAH or similar. If Mannkind decide to get serious about Afrezza and run decent trials then that would change. Right now I feel their focus is elsewhere, and that is fair enough since this is a business after all. Aged - now that we know afrezza does not make your lungs explode maybe you could help out sales and give it a try. Is your endo still concerned about long-term usage? Its been about 6 years. Is the need for a second dose still there? Although COVID and all remote meetings makes that easier than it was! I haven't asked him recently. He seems to be focusing quite heavily on SGLT2 and GLP-1 these days for Type 1. That's off-label I believe. |
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Post by cretin11 on Apr 27, 2021 15:06:32 GMT -5
I can't believe there are folks "out there" accusing people like aged of being stealth bashers, etc. It is a kind of crusade of mine to open people's eyes to the fact they do NOT in fact know a basher when they think they see one LOL. BD blowing the minds of a few folks on here. But they need to hear it, so thanks for telling it straight! |
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Post by BD on Apr 27, 2021 20:06:39 GMT -5
I've told the story of "tony" before, that was my eye-opener. When I was a "big fish bull" in this scam company 20 years ago (I even got a green ceramic fish-shaped flower vase as a gift at one of the few social get-togethers of local folks all caught up in the scam), I watched tony get raked over the coals when he posted about danger signals. I know what it feels like to be SURE the investment is going to make me rich and have others try to be party poopers.
Ever since then, I've been a lot less easy to convince that any particular person is a "basher", stealth or otherwise. I believe there's a lot more to be learned from giving the benefit of the doubt than to go on a witch hunt.
There's an apropos quote that goes by on the home page quote scroll. Look for it.
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Post by longliner on Apr 27, 2021 23:04:57 GMT -5
... We are very fortunate to have the level of moderators we have, even so the hired folks are welcome here too, as long as they behave (as are we). As I've said, Aged was / is one of my favorite posters, an extremely bright individual in both finance and medicine. Even though I am no match for his intellect, he seemed to enjoy a bit of verbal jousting. ... Now you are making me blush TBH my interest in Mannkind is chiefly Afrezza. Most of the focus these days is UTHR and that isn't really of interest to me since happily I don't have PAH or similar. If Mannkind decide to get serious about Afrezza and run decent trials then that would change. Right now I feel their focus is elsewhere, and that is fair enough since this is a business after all. Welcome back! Congratulations on surviving the pandemic, I hope your family across the pond is well also. I am still curious as to why the interest in Afrezza, you admittedly have not tried it, you don't (I believe) invest money in it, yet as a diabetic you must by now acknowledge the safety profile? You have had so many comments on it over the years, it almost seems like "this is a business after all"😉. Now don't get PAH or we will have 5,000 posts about how this treatment is just not quite right for you.😂 I believe YOUR focus became, somewhat abruptly, elsewhere. All the same, good to see your posts. Be well. |
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Post by sportsrancho on Apr 28, 2021 9:02:33 GMT -5
It is fairly simple to get excellent results with Afrezza without very many follow-up doses if you use the right protocols. And the patient gets the right amount of training.
Like aged says....getting serious about the studies/trials is key.
Referring patients out to the right protocols would be huge.
Their attention is elsewhere which is fine and good. But whenever they want to take Afrezza off the back burner..... The solutions are within reach:-)
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Post by straightly on Apr 28, 2021 18:43:39 GMT -5
It is fairly simple to get excellent results with Afrezza without very many follow-up doses if you use the right protocols. And the patient gets the right amount of training. Like aged says....getting serious about the studies/trials is key. Referring patients out to the right protocols would be huge. Their attention is elsewhere which is fine and good. But whenever they want to take Afrezza off the back burner..... The solutions are within reach:-) And they have the resources now. They simply can’t/shouldn’t let Afrezza go the way side without another different and significant marketing effort. |
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Post by bones1026 on Apr 28, 2021 21:11:15 GMT -5
Now you are making me blush TBH my interest in Mannkind is chiefly Afrezza. Most of the focus these days is UTHR and that isn't really of interest to me since happily I don't have PAH or similar. If Mannkind decide to get serious about Afrezza and run decent trials then that would change. Right now I feel their focus is elsewhere, and that is fair enough since this is a business after all. Welcome back! Congratulations on surviving the pandemic, I hope your family across the pond is well also. I am still curious as to why the interest in Afrezza, you admittedly have not tried it, you don't (I believe) invest money in it, yet as a diabetic you must by now acknowledge the safety profile? You have had so many comments on it over the years, it almost seems like "this is a business after all"😉. Now don't get PAH or we will have 5,000 posts about how this treatment is just not quite right for you.😂 I believe YOUR focus became, somewhat abruptly, elsewhere. All the same, good to see your posts. Be well. 🎯 |
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Post by BD on Apr 28, 2021 21:59:46 GMT -5
I had to make my screen be about 500% bigger to see what that is, but it makes me grateful to finally have a laptop with a touchscreen...
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Post by agedhippie on Apr 30, 2021 10:38:39 GMT -5
Welcome back! Congratulations on surviving the pandemic, I hope your family across the pond is well also. I am still curious as to why the interest in Afrezza, you admittedly have not tried it, you don't (I believe) invest money in it, yet as a diabetic you must by now acknowledge the safety profile? You have had so many comments on it over the years, it almost seems like "this is a business after all"😉. Now don't get PAH or we will have 5,000 posts about how this treatment is just not quite right for you.😂 I believe YOUR focus became, somewhat abruptly, elsewhere. All the same, good to see your posts. Be well. Why the interest in Afrezza? For the same reason that I am interest in pumps - I want diabetics to have options. I struggle to get past the idea of needing multiple dose personally. I don't like pumps, but the day they produce a working closed loop pump I will bite the bullet and be there lining up. You are correct though, right now I am way more focused on COVID than I am on Afrezza. Diabetes might kill me one day, but COVID is promising to do it much more immediately! A lot of what I post is the result of annoyance. I have seen a lot of posts from people who don't really understand the implications of being utterly dependent on a drug where fouling up can kill you in hours. There needs to be a very clear benefit to moving and a ton of reassurance that it's ok to move. Right now the data is neutral and the doctors are neutral at best, so why take the risk is probably a majority view. It is hard to convey exactly how careful diabetics are when it comes to insulin - it is beaten into you from day one. IMHO the way to get adoption is the well know, large scale trials and lots of studies in reputable journals. This is how it has always worked. Patronizing youtube ads of ice cream sales are so far from the mark that it's hard to convey. VDEX works well, but the scale is still small. |
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Post by straightly on Apr 30, 2021 11:44:21 GMT -5
Welcome back! Congratulations on surviving the pandemic, I hope your family across the pond is well also. I am still curious as to why the interest in Afrezza, you admittedly have not tried it, you don't (I believe) invest money in it, yet as a diabetic you must by now acknowledge the safety profile? You have had so many comments on it over the years, it almost seems like "this is a business after all"😉. Now don't get PAH or we will have 5,000 posts about how this treatment is just not quite right for you.😂 I believe YOUR focus became, somewhat abruptly, elsewhere. All the same, good to see your posts. Be well. Why the interest in Afrezza? For the same reason that I am interest in pumps - I want diabetics to have options. I struggle to get past the idea of needing multiple dose personally. I don't like pumps, but the day they produce a working closed loop pump I will bite the bullet and be there lining up. You are correct though, right now I am way more focused on COVID than I am on Afrezza. Diabetes might kill me one day, but COVID is promising to do it much more immediately! A lot of what I post is the result of annoyance. I have seen a lot of posts from people who don't really understand the implications of being utterly dependent on a drug where fouling up can kill you in hours. There needs to be a very clear benefit to moving and a ton of reassurance that it's ok to move. Right now the data is neutral and the doctors are neutral at best, so why take the risk is probably a majority view. It is hard to convey exactly how careful diabetics are when it comes to insulin - it is beaten into you from day one. IMHO the way to get adoption is the well know, large scale trials and lots of studies in reputable journals. This is how it has always worked. Patronizing youtube ads of ice cream sales are so far from the mark that it's hard to convey. VDEX works well, but the scale is still small. IMHO, the thing MNKD hasn’t figured out is a cost effective way to market Afrezza. “way to get adoption” as cited is simply too expensive and take too long. |
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Post by sportsrancho on Apr 30, 2021 15:53:56 GMT -5
Simple solution... put mnholdem on the board and get the marketing done, put Bill on the board and get the studies done.
Mnholdem didn’t get to give you his ideas which he was all set to do if he got on the ballot. He is the administrator of dozens of multiple global companies.. it’s his expertise.
And Afrezza is Bill’s expertise.
Vote!
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Post by shawnonafrezza on Apr 30, 2021 19:10:18 GMT -5
Welcome back! Congratulations on surviving the pandemic, I hope your family across the pond is well also. I am still curious as to why the interest in Afrezza, you admittedly have not tried it, you don't (I believe) invest money in it, yet as a diabetic you must by now acknowledge the safety profile? You have had so many comments on it over the years, it almost seems like "this is a business after all"😉. Now don't get PAH or we will have 5,000 posts about how this treatment is just not quite right for you.😂 I believe YOUR focus became, somewhat abruptly, elsewhere. All the same, good to see your posts. Be well. Why the interest in Afrezza? For the same reason that I am interest in pumps - I want diabetics to have options. I struggle to get past the idea of needing multiple dose personally. I don't like pumps, but the day they produce a working closed loop pump I will bite the bullet and be there lining up. You are correct though, right now I am way more focused on COVID than I am on Afrezza. Diabetes might kill me one day, but COVID is promising to do it much more immediately! A lot of what I post is the result of annoyance. I have seen a lot of posts from people who don't really understand the implications of being utterly dependent on a drug where fouling up can kill you in hours. There needs to be a very clear benefit to moving and a ton of reassurance that it's ok to move. Right now the data is neutral and the doctors are neutral at best, so why take the risk is probably a majority view. It is hard to convey exactly how careful diabetics are when it comes to insulin - it is beaten into you from day one. IMHO the way to get adoption is the well know, large scale trials and lots of studies in reputable journals. This is how it has always worked. Patronizing youtube ads of ice cream sales are so far from the mark that it's hard to convey. VDEX works well, but the scale is still small. From T1 to T1, AndroidAPS has a few people running it with modifications (not public yet) that get amazing results without announcing meals even. Literally at the plug and play point. I wish I was more tolerant of the results he gets (I try to stay A1C < 5.5) and could tolerate/trust pumps more. Also Lyumjev made my sites sore on bolus which was a literal PITA. I put all my hopes in to cell based encapsulation for the next real advancement. |
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Post by akemp3000 on May 1, 2021 5:38:23 GMT -5
It's great to see all the various attempts at advancing and improving diabetes treatment. This is especially true considering the former Chief Scientific Officer for the American Diabetes Association called today's standards of care antiquated and barbaric. We also know that endos today follow the recommended standards of care and put patients on a horrible treat to failure path. With new options available, it's hard to imagine being diagnosed with diabetes and stepping on that antiquated treadmill yet most everyone does since the public at large isn't aware of all the knowledge and advancements discussed on this board.
IMO, Afrezza remains the leader in improving quality of life for most diabetics once the user understands dosing such as that being promoted by VDex. The thought of having to rely on new devices and daily or even hourly chart reading does not sound like a great quality of life though it's understood this may be necessary and is certainly better than no life. I remain convinced Afrezza is the greatest advancement in diabetic quality of life in a generation and look forward to the day a BP steps in with big money and shares this awareness with all diabetics globally.
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Post by shawnonafrezza on May 1, 2021 9:23:21 GMT -5
I'm cautious that there is a "best treatment". Every diabetic is different and has different needs and wants. If someone wants a no touch solution Afrezza will not be best just like if someone doesn't want to be attached to a device a pump is not best. At the moment is is (part of) the best treatment for me but I fully understand why Tim in the graph above does what he does and Afrezza would not be best for him.
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Post by agedhippie on May 1, 2021 9:58:26 GMT -5
From T1 to T1, AndroidAPS has a few people running it with modifications (not public yet) that get amazing results without announcing meals even. Literally at the plug and play point. ... I wish I was more tolerant of the results he gets (I try to stay A1C < 5.5) and could tolerate/trust pumps more. Also Lyumjev made my sites sore on bolus which was a literal PITA. I put all my hopes in to cell based encapsulation for the next real advancement. That is an amazing graph. I haven't tried any of the new RAA insulin yet, I am still getting comfortable with the idea of the additives. That said Lyumjev does look interesting although the site reaction is a concern. |
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