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Post by stanleyttu on Jan 3, 2022 16:39:24 GMT -5
I agree on the speed. It really does have that, and it makes total sense because it uses the lungs to circulate. My coughing didn't improve with time, though. I wish it did.
I'm not trying to be a debbie downer, and I have plenty invested in MNKD to irrationally pump the company if I wanted. I just want to temper people's expectations. It is a good option for many, but it shouldn't be looked at as some sort of game-changer that is going to overcome the rest of the insulin market.
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Post by lakon on Jan 3, 2022 17:10:09 GMT -5
Right… I just seen no evidence of that whatsoever. Not until we prove we can scale here in the US. I think Mike is on a path to sign the global partner. He wants to do new drug development and be the manufacturer for the partnered products. He has mentioned signing the global partner on several calls. Thats the only hard evidence I can give you now. Until the partner is signed they will hedge and continue on the current path and try and expand sales. IMO, MNKD can never scale as long as they have the boot of the ADA/BP on their neck. Maybe Al could have brute forced things but its near impossible without Al. We don't even have Dave Kendall who had a chance. Dave thought it was going to be a piece of cake. They need a partner with the technology and resources to pull this off and is willing to give the current diabetes medical community the middle finger. The latest SoC is so confusing they tried to flow chart things out. Its such a mess. Whoever the partner is needs to be willing to steamroll this mess. CGM technology has proven afrezza is the real deal, As Mango said, the Holy Grail of Diabetes. What would happen if Amazon did a deal and made a huge contribution to the ADA? I'm just saying... |
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Post by cedafuntennis on Jan 3, 2022 17:57:32 GMT -5
What happens if you have a sip of water before inhaling? I am asking as I feel so bad that A is not working for you. I have a couple of friends who are in desperate need to Afrezza but are unable to take it (doctor related, not coughing) and one friend who is taking it and reporting life changing results for his that I feel so bad for you that you are not reacting so well to it. My friend said that the sip of water before helped. Didn't ask him if a Jack Daniels would have helped, but I suspect not good to mix the two. :-)
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Post by sayhey24 on Jan 3, 2022 18:17:29 GMT -5
I agree on the speed. It really does have that, and it makes total sense because it uses the lungs to circulate. My coughing didn't improve with time, though. I wish it did. I'm not trying to be a debbie downer, and I have plenty invested in MNKD to irrationally pump the company if I wanted. I just want to temper people's expectations. It is a good option for many, but it shouldn't be looked at as some sort of game-changer that is going to overcome the rest of the insulin market. Stanley - I don't think anyone here is "pumping" the company. Its just there are some of us who are true believers. Al Mann was such a true believer he did study after study trying to prove afrezza was not as good as it appeared. In the end Al put nearly a $B into its development. IMO, MNKD true believers are like the old Apple Cult who were such true believers and who kept Apple going back in the day when they needed a loan from Bill Gates to keep it going. If you have a healthy liver and aren't using other meds which will interfere, the liver is going to prevent the severe hypo. With a healthy person the pancreas just boluses pretty much what it did the last time you ate. It has no idea how much sugar it going to be in the system. If after a while the BG is too high it releases more and more. At some point the BG is going to start going low and along comes the liver. Now, if you are sitting at 280 prior to eating and then taking afrezza after eating you may want to give VDex a call. The idea is basically to follow what Richard Bernstein outlined for BG control years ago but using afrezza to do what he did through extreme diet control. Afrezza also provides the ability to immediately correct for high BG which Bernstein never had. Its also a well know fact that once you are sitting in the 200's bringing down that high is much different than controlling the mealtime spike if you are at a near normal baseline. I would think VDex could provide some guidance here. Most people who inhale with a long slow inhalation don't cough but nothing is perfect. We had Amy Tenderich from Diabetesmine back in the day saying it didn't work at all as she posted a picture using the inhaler upside down. Once she turned it the right way she got much better results. |
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Post by sayhey24 on Jan 3, 2022 18:28:53 GMT -5
What happens if you have a sip of water before inhaling? I am asking as I feel so bad that A is not working for you. I have a couple of friends who are in desperate need to Afrezza but are unable to take it (doctor related, not coughing) and one friend who is taking it and reporting life changing results for his that I feel so bad for you that you are not reacting so well to it. My friend said that the sip of water before helped. Didn't ask him if a Jack Daniels would have helped, but I suspect not good to mix the two. :-) A finger and a half of Old Number 7 before bed does better for me than what metformin would in keeping my fasting BG in the low 90's. Although I will say the Kirkland brand will do the same at half the price and I think its better. Mixing the whiskey with the basal I have no personal experience with but I would proceed with caution as the liver is already out of whack with the basal. The sip of water and a slow steady deep inhalation usually helps with the cough. Its good the water helped your friend and afrezza is working out so well. |
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Post by sellhighdrinklow on Jan 3, 2022 20:05:56 GMT -5
Rye whiskey and Afrezza mix fine together. Experienced mixer here 🙃
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Post by buyitonsale on Jan 4, 2022 17:11:18 GMT -5
As I read these testimonials about issues with Afrezza, I always think that if I had T1D, I would try everything possible to overcome them: correct angle of holding the device, water before and after inhalation, correct inhalation technique, multiple inhalations to make sure that no powder is left in the cartridge, use CGM to dial in dosing and control, etc.
Because that curve that Afrezza produces is the closest to real pancreatic insulin response and I would want the beast there is for me for mealtime control.
Why do people settle for less than best when it comes to health ?
Every point above 5.6 A1C is not good, and if T1D patient is above that they should try harder in every aspect (including turning down the carb knob).
T2D patients I simply do not get, because it is a self inflicted condition and completely reversible with diet and lifestyle changes. Unless it was misdiagnosed and is really T1 (LADA).
All in my opinion, of course.
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Post by sportsrancho on Jan 4, 2022 20:15:54 GMT -5
Bill will speak to this is soon as he gets time.
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Post by sayhey24 on Jan 5, 2022 12:35:06 GMT -5
Bill will speak to this is soon as he gets time. Sports - I wonder if Bill could use Stanley as a case study for VDex? Here we have someone who says they would really like to use afrezza but are hypersensitive to the powder and just cough it out. I am sure many on this board would be interested in the results. |
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Post by sportsrancho on Jan 5, 2022 14:16:52 GMT -5
Bill will speak to this is soon as he gets time. Sports - I wonder if Bill could use Stanley as a case study for VDex? Here we have someone who says they would really like to use afrezza but are hypersensitive to the powder and just cough it out. I am sure many on this board would be interested in the results. You wouldn’t believe how many of those we have! People from the Afrezza Facebook page. I get them hooked up with Claudia. She blows them away with her results! For whoever doesn’t know that’s our head provider in Las Cruces New Mexico. |
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Post by prcgorman2 on Jan 5, 2022 20:36:22 GMT -5
Sports - I wonder if Bill could use Stanley as a case study for VDex? Here we have someone who says they would really like to use afrezza but are hypersensitive to the powder and just cough it out. I am sure many on this board would be interested in the results. You wouldn’t believe how many of those we have! People from the Afrezza Facebook page. I get them hooked up with Claudia. She blows them away with her results! For whoever doesn’t know that’s our head provider in Las Cruces New Mexico. The Land of Enchantment! |
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Post by sayhey24 on Jan 7, 2022 11:35:41 GMT -5
Sports - I wonder if Bill could use Stanley as a case study for VDex? Here we have someone who says they would really like to use afrezza but are hypersensitive to the powder and just cough it out. I am sure many on this board would be interested in the results. You wouldn’t believe how many of those we have! People from the Afrezza Facebook page. I get them hooked up with Claudia. She blows them away with her results! For whoever doesn’t know that’s our head provider in Las Cruces New Mexico. Sports - I went back through the VDex whitepapers. There is some good stuff in those papers with experience from over 500 PWDs as of 2020. I am afraid these papers are like the tress in the forest which have fallen and no one hears them. They also mention the data seems too good and the diabetes community tells them their results can't be this good. Is there a plan to get this info more widely published? Are they currently working with one of the "smart" apps like a Gluroo? I would still like to see Stanley as a case study since he was an afrezza user who says it didn't work for him. |
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Post by sportsrancho on Jan 7, 2022 11:58:18 GMT -5
You wouldn’t believe how many of those we have! People from the Afrezza Facebook page. I get them hooked up with Claudia. She blows them away with her results! For whoever doesn’t know that’s our head provider in Las Cruces New Mexico. Sports - I went back through the VDex whitepapers. There is some good stuff in those papers with experience from over 500 PWDs as of 2020. I am afraid these papers are like the tress in the forest which have fallen and no one hears them. They also mention the data seems too good and the diabetes community tells them their results can't be this good. Is there a plan to get this info more widely published? Are they currently working with one of the "smart" apps like a Gluroo? I would still like to see Stanley as a case study since he was an afrezza user who says it didn't work for him. Yes and Bill will respond as soon as he gets a chance. |
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Post by sportsrancho on Jan 7, 2022 16:27:03 GMT -5
Response to Stanleyttu post of Jan 3, 2022:
I hope you take what I write in the best sense, which is what I intend. I have a very different view of Afrezza from yours. I truly believe it is the holy grail for diabetes and the future of MannKind Corporation. I believe it will become the standard of care. I believe it will change the fortunes of all investors in MannKind.
Your experience is your experience. Through my experience at Vdex I have seen hundreds of patients whose experiences are much different. I suspect you didn’t get the best guidance in your use of Afrezza. I’m offering to help…with one condition: let’s do this publicly on the message board so others can see. I don’t intend to disparage your experience. I’m sure you did the best you could with the advice you got. I’m only saying it wasn’t the best advice. I think you would have a different feeling with better guidance. And, I’d like investors and prospective patients to see what happens with proper instruction.
I can tell from what you’ve written that you understand a lot about Afrezza, but there’s more to it that you may not know. Also, as a person with Type 1, you are steeped in diabetes management 24x7x365. I respect that perspective. It’s life and death for you. Here’s what I want to say that may be different from what you’ve learned: the current treatment paradigm for diabetes is actually backward. It can be summarized by a phrase used to describe it from a couple decades ago: Fix Fasting First (FFF). This was/is the overarching approach to managing diabetes…and it’s wrong.
To be clear, FFF developed because it was the best approach at the time given the tools available. But, with Afrezza all that changes. The real problem in BG control is prandial control. At mealtimes is when BG goes most out of control, not at 3:00am when a person is asleep. So, I have coined a phrase for what we’re doing at Vdex: Mainly Manage Mealtime (MMM). Couldn’t resist the alliteration.
Now, to address some specifics about your use, I think we can alleviate much, if not all, the cough you experienced. That’s very technique-dependent. There are ways to minimize it, and then once your body acclimates to the powder, it almost completely disappears. This, as you point out, will affect dosing. So, once we get consistent intake, we can adjust dosing, an area also subject to a fair amount of nuance. Last point, because of the broad safety margin with Afrezza the is a surprising amount of leeway in dosing.
My offer is to work with you to get you under better control. I’d like to see if your perspective on Afrezza might change. If you want to do it privately, that’s ok too. I just thought since you have been public with your negative experience, you might want to do so if it is positive.
Best Regards to you,
Bill McCullough
CEO/Founder – Vdex Diabetes
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Post by mymann on Jan 7, 2022 17:08:10 GMT -5
Response to Stanleyttu post of Jan 3, 2022: I hope you take what I write in the best sense, which is what I intend. I have a very different view of Afrezza from yours. I truly believe it is the holy grail for diabetes and the future of MannKind Corporation. I believe it will become the standard of care. I believe it will change the fortunes of all investors in MannKind. Your experience is your experience. Through my experience at Vdex I have seen hundreds of patients whose experiences are much different. I suspect you didn’t get the best guidance in your use of Afrezza. I’m offering to help…with one condition: let’s do this publicly on the message board so others can see. I don’t intend to disparage your experience. I’m sure you did the best you could with the advice you got. I’m only saying it wasn’t the best advice. I think you would have a different feeling with better guidance. And, I’d like investors and prospective patients to see what happens with proper instruction. I can tell from what you’ve written that you understand a lot about Afrezza, but there’s more to it that you may not know. Also, as a person with Type 1, you are steeped in diabetes management 24x7x365. I respect that perspective. It’s life and death for you. Here’s what I want to say that may be different from what you’ve learned: the current treatment paradigm for diabetes is actually backward. It can be summarized by a phrase used to describe it from a couple decades ago: Fix Fasting First (FFF). This was/is the overarching approach to managing diabetes…and it’s wrong. To be clear, FFF developed because it was the best approach at the time given the tools available. But, with Afrezza all that changes. The real problem in BG control is prandial control. At mealtimes is when BG goes most out of control, not at 3:00am when a person is asleep. So, I have coined a phrase for what we’re doing at Vdex: Mainly Manage Mealtime (MMM). Couldn’t resist the alliteration. Now, to address some specifics about your use, I think we can alleviate much, if not all, the cough you experienced. That’s very technique-dependent. There are ways to minimize it, and then once your body acclimates to the powder, it almost completely disappears. This, as you point out, will affect dosing. So, once we get consistent intake, we can adjust dosing, an area also subject to a fair amount of nuance. Last point, because of the broad safety margin with Afrezza the is a surprising amount of leeway in dosing. My offer is to work with you to get you under better control. I’d like to see if your perspective on Afrezza might change. If you want to do it privately, that’s ok too. I just thought since you have been public with your negative experience, you might want to do so if it is positive. Best Regards to you, Bill McCullough CEO/Founder – Vdex Diabetes Sports you are very fortunate to work for a leader that understands the product and how to teach patients on using Afrezza. |
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