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Post by sportsrancho on Dec 17, 2015 17:16:14 GMT -5
Sax, yes saw that about the 20unit. Funny how some people miss the real news. And listen to the wrong people.Things will get real exciting:-) Thank-you!
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Post by compound26 on Dec 17, 2015 17:23:52 GMT -5
Sax, yes saw that about the 20unit. Funny how some people miss the real news. And listen to the wrong people.Things will get real exciting:-) Thank-you! Rozale probably will be very interested in 20 units as I remember he needs high dosages of Afrezza. And the 20 units will be much cheaper per unit wise. |
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Post by peppy on Dec 17, 2015 17:33:42 GMT -5
Sax, yes saw that about the 20unit. Funny how some people miss the real news. And listen to the wrong people.Things will get real exciting:-) Thank-you! Rozale probably will be very interested in 20 units as I remember he needs high dosages of Afrezza. And the 20 units will be much cheaper per unit wise. sports and compound, and all, with your knowledge of Afrezza, is one higher dose better, or two doses with time in between?
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Post by sportsrancho on Dec 17, 2015 17:51:32 GMT -5
Rozale probably will be very interested in 20 units as I remember he needs high dosages of Afrezza. And the 20 units will be much cheaper per unit wise. sports and compound, and all, with your knowledge of Afrezza, is one higher dose better, or two doses with time in between?
The kids were taking the 8u for meals and the 4u for snacks. But now are on the 12u. I don't think they needed a follow up dose but I will ask their dad. I know he said that they did not need the 2u. |
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Post by kball on Dec 17, 2015 19:39:06 GMT -5
I do worry (a little) that the 20 may be a lot of powder.
I wonder how it compares particle wise to my long acting asthma inhaler (which often times seems like i get differing doses)
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Post by robsacher on Dec 17, 2015 22:00:34 GMT -5
Does my memory serve, but wasn't there some fiasco around WebMD and Afrezza a while back? There were early users commenting and they wiped out the comments under the premise that they were fraudulent or something? Or am I getting Affrezheimers? Yes, you are correct. But, Sanofi is now spending $ on advertising Toujeo so perhaps WebMD will put something positive up about Afrezza, another Sanofi product. In the music business, record labels would spend large amounts of $ advertising certain new albums at radio stations to insure that the radio stations played another artist on that record label. That way, payola was avoided... |
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Post by irashorr on Dec 18, 2015 1:16:27 GMT -5
The Wed MD news--the Stocktwits posts--this thread has me feeling more optimistic than I've been in ages. Along with other promising signals. Is that the light I see....
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Post by logel on Dec 18, 2015 6:57:55 GMT -5
www.webmd.com/diabetes/guide/diabetes-types-insulin#1Afrezza, a rapid-acting inhaled insulin, is FDA-approved for use before meals for both type 1 and type 2 diabetes. The drug peaks in your blood in about 15-20 minutes and it clears your body in 2-3 hours. It must be used along with long-acting insulin in people with type 1 diabetes. I am a not a diabetic and didn't read the drug info, but shouldn't it read ' at the start of the meal' or even ' a few minutes after the start of the meal' instead? Using Afrezza like 10 minutes before meals guarantees underwhelming results, so much I have learned. Or am I missing something? |
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Post by cretin11 on Dec 18, 2015 7:06:58 GMT -5
I thought the same thing, logel.
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Post by sportsrancho on Dec 22, 2015 16:49:44 GMT -5
Rozale probably will be very interested in 20 units as I remember he needs high dosages of Afrezza. And the 20 units will be much cheaper per unit wise. sports and compound, and all, with your knowledge of Afrezza, is one higher dose better, or two doses with time in between?
About the kids. They do not need a second dose. They take the 8 or 12 after they start the meal and only if they are at a fancy restaurant where the meal lasts a long time and then they have dessert at the end do they use a second dose. Maybe a 4 unit. Using the 8 or 12 depends on the amount of carbs in the meal. So one higher dose works the best for them. |
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Post by jpg on Dec 22, 2015 17:04:31 GMT -5
sports and compound, and all, with your knowledge of Afrezza, is one higher dose better, or two doses with time in between?
About the kids. They do not need a second dose. They take the 8 or 12 after they start the meal and only if they are at a fancy restaurant where the meal lasts a long time and then they have dessert at the end do they use a second dose. Maybe a 4 unit. Using the 8 or 12 depends on the amount of carbs in the meal. So one higher dose works the best for them. I would think that because of the unique PK/PD this is the most logical way of taking Afrezza. Sadly most 'experts' will have a lot of difficulty figuring this out. They play it 'safe' and take to little and to early. Then they need more later. Kids learn faster! |
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Post by compound26 on Dec 22, 2015 17:17:03 GMT -5
About the kids. They do not need a second dose. They take the 8 or 12 after they start the meal and only if they are at a fancy restaurant where the meal lasts a long time and then they have dessert at the end do they use a second dose. Maybe a 4 unit. Using the 8 or 12 depends on the amount of carbs in the meal. So one higher dose works the best for them. I would think that because of the unique PK/PD this is the most logical way of taking Afrezza. Sadly most 'experts' will have a lot of difficulty figuring this out. They play it 'safe' and take to little and to early. Then they need more later. Kids learn faster!
They probably will figure out the optimal timing and dosage of Afrezza in a few days and hence see great results from Afrezza in a few days whereas many adults/experts will try once and twice (based on their existing habits on RAAs) and then claim it doesn't work well for them. See the results the kids are having: www.13abc.com/home/headlines/Inhaled-Insulin-now-helping-diabetics-362524351.htmlIf the above assumption is true, it appears it would be a great idea for Sanofi to prove superiority of Afrezza via a pediatric trial. Now considering that all the participants in the pediatric trial must have a CGM, maybe there is something to that effect in the trial design.Even if the current ongoing pediatric trial maybe too small (46 participants) as a superiority/label improvement study, it appears the data Sanofi collects from such study will greatly help Sanofi design the actual superiority/label improvement study. See some of the unsuccessful trails of Afrezza made by some of the experts (including Endos) on Afrezza: www.healthline.com/diabetesmine/afrezza-focus-group-feedbackMatt. B would be an ideal Endo to spread the words of Afrezza to patients. He's doing many tests/experiments on timing and dosing on different type of foods/situations. That is the thing Afrezza uers should do. Plus, I would think most kids hate injections (more than adults do) and kids generally love to try out and be linked to new/novel things (which Afrezza is).
For the above reasons, will the pediatric diabetic markets be the best/ideal markets for Afrezza?
Maybe. I think that will be the case once the pediatric trial is done, especially with some kind of superiority label attached to Afrezza by then. |
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Post by suebeeee1 on Dec 22, 2015 19:00:09 GMT -5
Pediatric the ideal?. Clearly Afrezza is perfect for kids, but it is perfect for everyone else too. I have no clue as to why Sanofi would want to market this primarily to children.
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Post by compound26 on Dec 22, 2015 19:15:28 GMT -5
Pediatric the ideal?. Clearly Afrezza is perfect for kids, but it is perfect for everyone else too. I have no clue as to why Sanofi would want to market this primarily to children. I think Afrezza is good and great for every diabetic that needs (or should use) meal time insulin. It just appears to me that the pediatric markets may be more accessible (once the pediatric trial is completed, of course) compared with the adult market giving that kids are more prone to like/try out new/cool things. |
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