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Post by stevil on Feb 27, 2016 18:32:31 GMT -5
I know someone that works at Lilly in the marketing/research department. I was told that they were very excited about a pump in the near future that will read blood sugar in real time and release either insulin or glucagon to keep the blood within physiological limits. It's effectively an artificial pancreas. I'm not sure if this is similar to that or not, but thought I'd share what I'd heard. They weren't allowed to divulge too many details. That's about all that I know about it. One thing that artificial pumps can't handle is glucose spikes during eating, or that is what I have read from those who follow AP closely. We do know that Sansum has done AP testing and used Afrezza as the meal time insulin. Here's the video. www.youtube.com/watch?v=GGgGjtM5ipgTrue, but there's also some sort of machinery that will bolus for you. You type in how many carbs you're about to eat, and I think it's even supposed to beep for you when the best time to eat would be. Then, if you miscalculated, or if there are any complications with metabolism, the glucagon would correct on the over or more insulin would be released on the under. In theory, it could do away with injections altogether. The only involvement would come during mealtime and all that is required is carb counting. No other maintenance is required other than making sure the vials aren't empty. I have no idea how large the device would be or how the vials will be loaded, but it sounded interesting nonetheless. I notice that I feel angst towards it because it's a threat to my investment, but I have to remember that this is about saving lives, not about making money off of people's' diseases. It's remarkable technology and very exciting what medicine is evolving into. |
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Post by stevil on Feb 27, 2016 18:36:59 GMT -5
The point with the artificial pancreas is that you go not need to do anything other than periodically top up a pump and change a site or sensor. You can eat when and what you want without any manual dosing, you can exercise, you can live a normal life without worrying whether you are high or low. It will be expensive though and beyond most Type 1 and a few Type 2 diabetics nobody else will get it in the US. pump and a normal life? there's nothing normal with a pump.. Sorry to pick on you, but I take issue with people that talk like this on here. I have no idea if you're diabetic, but if you are, I have a hard time imagining you'd say something like this. For people like my uncle who grew up without a pump, he feels like he's a free man with his pump. I tried to tell him about Afrezza but he was perfectly content with his pump so he didn't even listen to me. Does it get better than a pump? Yes. Is no pump better than a pump? Yes. Forgive my candor, but you sound ignorant when you talk like this. And it's self-talk like this that I feel many people deceived themselves into thinking Afrezza was more than it was. Afrezza doesn't even remove the necessity of a pump for crying out loud (correction: it can for type 2s if it relieves beta exhaustion, but not type 1s)! Pumps are wonderful things! It's the closest diabetics have gotten to "normal" since the beginning of time. It's not the destination, but it's certainly a significant step in the right direction. Please don't downplay its significance. |
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Post by Deleted on Feb 27, 2016 18:53:02 GMT -5
pump and a normal life? there's nothing normal with a pump.. Sorry to pick on you, but I take issue with people that talk like this on here. I have no idea if you're diabetic, but if you are, I have a hard time imagining you'd say something like this. For people like my uncle who grew up without a pump, he feels like he's a free man with his pump. I tried to tell him about Afrezza but he was perfectly content with his pump so he didn't even listen to me. Does it get better than a pump? Yes. Is no pump better than a pump? Yes. Forgive my candor, but you sound ignorant when you talk like this. And it's self-talk like this that I feel many people deceived themselves into thinking Afrezza was more than it was. Afrezza doesn't even remove the necessity of a pump for crying out loud! Pumps are wonderful things! It's the closest diabetics have gotten to "normal" since the beginning of time. It's not the destination, but it's certainly a significant step in the right direction. Please don't downplay its significance. I am not downplaying pump.. I am just saying pump is not normal... You wouldnt know the freedom until you have gone pump free |
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Post by agedhippie on Feb 27, 2016 18:55:13 GMT -5
The point with the artificial pancreas is that you go not need to do anything other than periodically top up a pump and change a site or sensor. You can eat when and what you want without any manual dosing, you can exercise, you can live a normal life without worrying whether you are high or low. It will be expensive though and beyond most Type 1 and a few Type 2 diabetics nobody else will get it in the US. pump and a normal life? there's nothing normal with a pump.. Trust me, as a Type 1 diabetic there is. |
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Post by stevil on Feb 27, 2016 18:56:49 GMT -5
Sorry to pick on you, but I take issue with people that talk like this on here. I have no idea if you're diabetic, but if you are, I have a hard time imagining you'd say something like this. For people like my uncle who grew up without a pump, he feels like he's a free man with his pump. I tried to tell him about Afrezza but he was perfectly content with his pump so he didn't even listen to me. Does it get better than a pump? Yes. Is no pump better than a pump? Yes. Forgive my candor, but you sound ignorant when you talk like this. And it's self-talk like this that I feel many people deceived themselves into thinking Afrezza was more than it was. Afrezza doesn't even remove the necessity of a pump for crying out loud! Pumps are wonderful things! It's the closest diabetics have gotten to "normal" since the beginning of time. It's not the destination, but it's certainly a significant step in the right direction. Please don't downplay its significance. I am not downplaying pump.. I am just saying pump is not normal... You wouldnt know the freedom until you have gone pump free I am not diabetic, so fortunately I've never been shackled to one. It sounds like you are now pump free and I'm very excited to hear that! Congrats. I hope many people share the same success you have with it! |
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Post by Deleted on Feb 27, 2016 19:09:39 GMT -5
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Post by stevil on Feb 27, 2016 19:15:50 GMT -5
I'm not understanding why people are ditching their pumps when they still take a basal? Is it just because they don't want to have something clunky attached to them and would trade that freedom for the cost of injecting? next stop, inhalable basal insulin haha. Afrezza + tresiba combo pack. Probably when the patent expires.... That's usually how these things go... For those interested in the Lilly pump, I did a quick search and found this. diatribe.org/bionic-pancreas-dual-chamber-pump-unveiled-friends-life-2015And a couple mistakes in my previous post. I guess you type in more either, snack, small, medium, large meal and then you're done. Something like that. No carb counting. www.healthline.com/diabetesmine/cwd-friends-for-life-2015#4 |
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Post by agedhippie on Feb 27, 2016 20:50:18 GMT -5
I'm not understanding why people are ditching their pumps when they still take a basal? Is it just because they don't want to have something clunky attached to them and would trade that freedom for the cost of injecting? next stop, inhalable basal insulin haha. Afrezza + tresiba combo pack. Probably when the patent expires.... That's usually how these things go... For those interested in the Lilly pump, I did a quick search and found this. diatribe.org/bionic-pancreas-dual-chamber-pump-unveiled-friends-life-2015And a couple mistakes in my previous post. I guess you type in more either, snack, small, medium, large meal and then you're done. Something like that. No carb counting. www.healthline.com/diabetesmine/cwd-friends-for-life-2015#4Your basal levels fluctuate throughout the day. One of the big gains in a pump is the ability to fit that curve which you cannot do with an injection. You can also run into problems exercising because the injected basal obviously cannot be suspended whereas a pump can. I want an artificial pancreas - I don't want just breathe, I want to just live! |
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Post by Deleted on Feb 27, 2016 20:56:01 GMT -5
I'm not understanding why people are ditching their pumps when they still take a basal? Is it just because they don't want to have something clunky attached to them and would trade that freedom for the cost of injecting? next stop, inhalable basal insulin haha. Afrezza + tresiba combo pack. Probably when the patent expires.... That's usually how these things go... For those interested in the Lilly pump, I did a quick search and found this. diatribe.org/bionic-pancreas-dual-chamber-pump-unveiled-friends-life-2015And a couple mistakes in my previous post. I guess you type in more either, snack, small, medium, large meal and then you're done. Something like that. No carb counting. www.healthline.com/diabetesmine/cwd-friends-for-life-2015#4. One of the big gains in a pump is the ability to fit that curve which you cannot do with an injection. You can also run into problems exercising because the injected basal obviously cannot be suspended whereas a pump can. I want an artificial pancreas - I don't want just breathe, I want to just live! You may want to look @ tresiba and the good ole lantus - One injection a day..I wonder who got of those pumps after years of pumping are doing about their basal rates? live? she is |
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Post by agedhippie on Feb 27, 2016 21:14:15 GMT -5
Your basal levels fluctuate throughout the day. One of the big gains in a pump is the ability to fit that curve which you cannot do with an injection. You can also run into problems exercising because the injected basal obviously cannot be suspended whereas a pump can. I want an artificial pancreas - I don't want just breathe, I want to just live! You may want to look @ tresiba and the good ole lantus - One injection a day..I wonder who got of those pumps after years of pumping are doing about their basal rates? I have used Lantus although I split the dose because Lantus doesn't quite last 24 hours unless you are on large doses. I expect the people who got rid of their pumps live with the fluctuations and exercise problems because for them not having a pump is worth it. |
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Post by rockstarrick on Feb 27, 2016 23:07:48 GMT -5
The point with the artificial pancreas is that you go not need to do anything other than periodically top up a pump and change a site or sensor. You can eat when and what you want without any manual dosing, you can exercise, you can live a normal life without worrying whether you are high or low. It will be expensive though and beyond most Type 1 and a few Type 2 diabetics nobody else will get it in the US. Actually, mealtime glucose spikes were one of the biggest problems, (for lack of a better word) during the artificial pancreas studies. Afrezza was used in these studies to tackle these mealtime spikes. Heres the article, FYI mnkd.proboards.com/thread/4539/artificial-pancreas-race-finish |
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Post by careful2invest on Feb 27, 2016 23:44:22 GMT -5
This is the same concept as store within store, Apple, Samsung stores within Thousands of Best Buy stores nationwide. Apple, Samsung paid a lot to do just that. Small player can't afford that. Matt's slide mentioned large scale deployment. Good point. Why haven't they put up a disclaimer if they are an established company? Even if Dexcom is involved in it, why don't they disclose this? No need to hide. I do not think that anyone is hiding... However, I do believe that it is Verily and Dexcom (Vdex) and Sanofi will distribute Afrezza to them. And IMHO, the big reveal will be all at once for greatest impact! Time will tell! |
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Post by Deleted on Feb 28, 2016 7:14:35 GMT -5
Good point. Why haven't they put up a disclaimer if they are an established company? Even if Dexcom is involved in it, why don't they disclose this? No need to hide. I do not think that anyone is hiding... However, I do believe that it is Verily and Dexcom (Vdex) and Sanofi will distribute Afrezza to them. And IMHO, the big reveal will be all at once for greatest impact! Time will tell! there's nothing wrong in dreaming and hoping , but base it on facts... It was already posted v is flat lines and dex is dextrose. |
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Post by agedhippie on Feb 28, 2016 12:36:43 GMT -5
The point with the artificial pancreas is that you go not need to do anything other than periodically top up a pump and change a site or sensor. You can eat when and what you want without any manual dosing, you can exercise, you can live a normal life without worrying whether you are high or low. It will be expensive though and beyond most Type 1 and a few Type 2 diabetics nobody else will get it in the US. Actually, mealtime glucose spikes were one of the biggest problems, (for lack of a better word) during the artificial pancreas studies. Afrezza was used in these studies to tackle these mealtime spikes. Heres the article, FYI mnkd.proboards.com/thread/4539/artificial-pancreas-race-finishSpikes are a problem, although the AP can recover and bring you back into range quickly. Even so faster acting insulin would help a lot the current favorite Novo Nordisk FAIsp although I don't think that is fast enough either. The Sansum experiment was to model how an AP would behave with faster insulins however inhaled insulin obviously will not work in a production AP. |
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Post by peppy on Feb 28, 2016 13:29:09 GMT -5
Because the insulin delivery with the artificial pancreas is subq, the artificial pancreas is a story.
faster insulins... faster subj insulins.
hmmmmm.
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