Deleted
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Post by Deleted on Aug 13, 2016 13:19:34 GMT -5
Can you PM me? Mods please keep the thread open for a few hours?
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Post by peppy on Aug 13, 2016 13:29:03 GMT -5
Can you PM me? Mods please keep the thread open for a few hours? we can not know what the question is? curiosity killed the cat?
<--- female
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Post by michaelcastagna on Aug 13, 2016 17:31:18 GMT -5
I am a pharmacist:)
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Deleted
Deleted Member
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Post by Deleted on Aug 13, 2016 17:37:41 GMT -5
Oh No...I should have made it clear...a pharmacist who is currently working in a pharmacy.. Not the one who is working behind the scenes 4 freedom to all PWD :-) |
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Post by peppy on Aug 13, 2016 17:41:22 GMT -5
I want to say, What really grabbed my attention with afrezza was it is a monomer. Can we use that?
Afrezza, technosphere insulin, insulin delivered as a monomer. Insulin with an outsulin component.
I know I am a pill. What is a monomer caught by attention.
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Post by michaelcastagna on Aug 13, 2016 17:43:29 GMT -5
I have plenty of friends that work behind a counter. If there is some info I can get you just message me
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Post by kball on Aug 13, 2016 18:04:09 GMT -5
Can someone please confirm thats a SUNRISE in Michael Castagna's avatar and not a SUNSET? I'd feel better.
Michael?
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Post by derek2 on Aug 13, 2016 19:43:32 GMT -5
I want to say, What really grabbed my attention with afrezza was it is a monomer. Can we use that?
Afrezza, technosphere insulin, insulin delivered as a monomer. Insulin with an outsulin component.
I know I am a pill. What is a monomer caught by attention.
Actually, all rapid-acting insulins are monomers. RAAs are almost totally monomers and dimers with next to no hexamers. That was the whole point of developing them, and what made them rapid-acting. I suspect that some are skeptical of that kind of claim, since it runs counter to MNKD common wisdom, so here are some references: www.diapedia.org/management/8104096115/short-acting-insulin-analoguesen.wikipedia.org/wiki/Insulin_analogIt makes me wonder what Al was talking about when he said: Maybe he was just comparing Afrezza to Exhubera, which was indeed made from hexameric insulin, and stating that nobody had delivered monomeric insulin _to the lungs_ before. (even then, that wouldn't be much of a differentiator, since insulin hexamers immediately monomerize on the wet lung surface when inhaled or when injected into the blood. It's why you can crash if you mistakenly inject your basal insulin into muscle tissue) |
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Post by cabe1028 on Aug 13, 2016 21:11:55 GMT -5
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Post by cm5 on Aug 13, 2016 21:17:04 GMT -5
re: above two posts, comparing Mannkind's monomeric insulin with Exubera----and not to recognize the difference between Mannkind's monomeric insulin and Lispro, as per this post: mnkd.proboards.com/post/70707/thread |
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Post by anderson on Aug 13, 2016 21:20:41 GMT -5
Insulin Lispro
Short-acting insulin analogs are designed to overcome the limitations of conventional regular human insulin. Insulin lispro (Humalog), formerly called LYSPRO from the chemical nomenclature [LYS(B28), PRO(B29)], is the first commercially available insulin analog. Compared with regular human insulin, this insulin analog offers the advantages of faster subcutaneous absorption, an earlier and greater insulin peak, and a shorter duration of action.11,12
The benefits achieved by insulin lispro are related to a sequence switch of two beta-chain amino acids. Human insulin, a protein hormone composed of two polypeptide chains, has a linked A chain and B chain. In insulin lispro, reversal of the proline at B-28 and the lysine at B-29 results in more rapid dissolution of this insulin to a dimer and then to a monomer that is absorbed more rapidly after subcutaneous injection6 (Figure 1).13
more rapid dissolution from what?
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Post by agedhippie on Aug 13, 2016 22:13:45 GMT -5
Really nobody who uses insulin cares if Afrezza gets it's speed through monomers, delivery route, or unicorns and magic. I'm pretty certain that the vast majority of insulin users have no idea how insulin forms. Once you start to talk about monomers you are talking about features and not benefits. Next thing you know you have to educate the market - this is a bad thing.
The answer is it's fast, do you care why?
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Post by peppy on Aug 14, 2016 0:59:34 GMT -5
Really nobody who uses insulin cares if Afrezza gets it's speed through monomers, delivery route, or unicorns and magic. I'm pretty certain that the vast majority of insulin users have no idea how insulin forms. Once you start to talk about monomers you are talking about features and not benefits. Next thing you know you have to educate the market - this is a bad thing. The answer is it's fast, do you care why? For me aged, the reason I care is it is fascinating. A fascinating fact that may lead to interest. Because it is a fact, we can say it. (scream it from the mountain tops.) Afrezza, technosphere insulin. Insulin delivered as a monomer. Insulin with an Outsulin component.
.  The second phase, however, works like a small dose of injectable insulin. It lowers blood glucose, and takes longer to start working. This is the only phase of Humalog or Apidra.
Previous treatments work by flooding the body with an unnaturally high level of insulin for hours, in order to slowly lower high blood glucose levels. Afrezza stops blood glucose rising in the first place using the natural first phase signal to the liver instead. This means that for the first time much lower, more natural levels of insulin can now be used in Type 1 diabetics.
– Matt
afrezzadownunder.com/2015/09/afrezza-units-insulincarb-ratios/
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Post by peppy on Aug 14, 2016 2:26:25 GMT -5
Welcome. Thank you. Glad you are here. |
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Post by derek2 on Aug 14, 2016 6:54:33 GMT -5
Really nobody who uses insulin cares if Afrezza gets it's speed through monomers, delivery route, or unicorns and magic. I'm pretty certain that the vast majority of insulin users have no idea how insulin forms. Once you start to talk about monomers you are talking about features and not benefits. Next thing you know you have to educate the market - this is a bad thing. The answer is it's fast, do you care why? That's a great comment, although as a bithead, I'm personally drawn to feeds & speeds like a moth to the flame. My opinion on all of this is that it's the mode of administration - inhalation - that makes the biggest difference since it gets the insulin into the blood stream right away. It's also what leads to the shorter tail vs SC insulin since the insulin is more immediately available to be utilized / broken down. With SC insulin, it is by design that the drug is made more gradually available (even for "fast acting" insulin) due to it having to seep out from fatty tissue into the blood stream. I suspect that intramuscular injection of rapid-acting insulin would show similar PK/PD to compared to Afrezza (see here: www.ncbi.nlm.nih.gov/pubmed/2140087 ), including quick in / quick out, but that's WAY off-label, and who knows what kind of hypo risk could ensue. I'm not about to test that theory... |
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