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Post by afrezzamiracle on Nov 9, 2016 2:00:12 GMT -5
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Post by babaoriley on Nov 9, 2016 3:44:05 GMT -5
I just hope people who will use do so at home. After tonight, if I ever tell you that I'm predicting that the sun will rise in the morning, the likelihood is the world will end that night!
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Post by liane on Nov 9, 2016 5:23:22 GMT -5
I'm with you babaoriley. We do not yet have standards in place to determine level of impairment for marijuana use. |
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Post by nadathing on Nov 9, 2016 6:17:37 GMT -5
Just what we need. More people using mind altering substances. For some, it is recreation, but for many it is a way to escape the reality of the world they live in. God bless you if you are a recreational user who enjoys a good high over the influence of alcohol. It is, in my opinion, a healthier choice. As an alcoholic who has been sober for 12 years, I only hope that in 5 years we don't look back and regret the decision made yesterday.
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Post by falconquest on Nov 9, 2016 6:33:53 GMT -5
Just what we need. More people using mind altering substances. For some, it is recreation, but for many it is a way to escape the reality of the world they live in. God bless you if you are a recreational user who enjoys a good high over the influence of alcohol. It is, in my opinion, a healthier choice. As an alcoholic who has been sober for 12 years, I only hope that in 5 years we don't look back and regret the decision made yesterday. What's interesting about this whole topic is that while States legalize or "decriminalize" MJ, it's still illegal on a federal level. This brings up many issues including State's rights, levels of "intoxication", taxes etc. (Hmm, can States collect taxes on a substance that is illegal on a Federal level)? One thing we can all understand is that it has widespread use already so I'm not sure legalization will impact use to great degree. If you didn't use it before it was legal why would you necessarily use after it is? There is no doubt this will be interesting to watch. |
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Post by silentknight on Nov 9, 2016 7:13:30 GMT -5
Just what we need. More people using mind altering substances. For some, it is recreation, but for many it is a way to escape the reality of the world they live in. God bless you if you are a recreational user who enjoys a good high over the influence of alcohol. It is, in my opinion, a healthier choice. As an alcoholic who has been sober for 12 years, I only hope that in 5 years we don't look back and regret the decision made yesterday. What's interesting about this whole topic is that while States legalize or "decriminalize" MJ, it's still illegal on a federal level. This brings up many issues including State's rights, levels of "intoxication", taxes etc. (Hmm, can States collect taxes on a substance that is illegal on a Federal level)? One thing we can all understand is that it has widespread use already so I'm not sure legalization will impact use to great degree. If you didn't use it before it was legal why would you necessarily use after it is? There is no doubt this will be interesting to watch. It's an interesting dilemma but in the long run, yes, states can move forward with decriminalization. While it still might be illegal under federal law, it will be legal under state law which means that state and local law enforcement officials will no longer prosecute. The federal government still could, but that would mean DEA agents and other feds would have to be making street busts for a joint or two and then convince a U.S. Attorney to prosecute said subject, federally mind you, for a pretty minuscule amount of marijuana. That, I assure you will never happen. I work in this field. Street busts are never going to see the light of day in a federal court. Trafficking sure, but personal use wont. Even with Colorado and Washington earlier, the federal government has largely stayed out of the way. |
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Post by peppy on Nov 9, 2016 7:48:14 GMT -5
Haha, are you people kidding me with level of impairment stuff? Marijuana has been around for thousands of years. prior to 1929 40% of medicine in the USA had cannabis in it.
Cannabis will control epilisey, and arthritis better than the phrama chit that is being sold.
Additionally, in my world this country will require cannabis for the sedation needed to handle the Trump presidency.
Dumbed down with dope? or dumb down with out it? The drug trade money has been used to run the black ops in this country for years. Our country delivers drugs into the country for the cash and then confiscates users property for drug use. What a set up.
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Post by mnholdem on Nov 9, 2016 7:50:47 GMT -5
The new state laws limit the amount one may have in their possession. Where states will prosecute will like be for any illegal (that is, unlicensed & UNTAXED) production and distribution of marijuana. The feds role will become apparent when there is interstate transportation of marijuana that has not been produced by a licensed grower. Until the jurisdiction of federal laws become clearer, even a licensed grower may be prevented from transporting product across state lines under federal laws. What I appreciate about MannKind's deal with RLS is that RLS will become solely responsible for manufacturing. MannKind merely provides the paraphernalia (sorry, but I just couldn't resist using that description of the inhaler  ). If the API-TS being jointly (no pun intended) developed by MannKind and RLS is for the purpose of marketing a high-purity medical-grade FDA-approved API for repeated use with a cancer patient, then the DreamBoat (Gen2 Inhaler) will probably be the device used rather than a disposable cricket. Frankly, I don't see MannKind producing any kind of API for recreational use. Then again, after last night's election results, one lesson I've learned to accept that anything is possible in this country. |
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Post by matt on Nov 9, 2016 8:24:49 GMT -5
Decriminalizing small amounts of pot in states that tend to lean liberal is one thing, proclaiming that marijuana will be the savior of MNKD is something else. Afrezza is a drug regulated by the FDA, and marijuana is still a Schedule 1 drug along with other drugs of abuse. Has anybody thought through the blowback that will result at the FDA for participation in a marijuana project, or how MNKD can even benefit from it?
One of the biggest problems pot dispensaries have is that they are denied use of the banking system because the origin of their money is illegal, and they are likewise denied any deductions on their federal tax returns (i.e. they can't even deduct rent or payroll) due to the drug connection, while most illegal businesses are allowed deductions. If RLS makes milestone payments to MNKD, which will need to be in cash, how is that going to help the company if they can't deposit the money? It will take a change in federal law to alter the landscape, and that is a ways off.
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Post by mnkdfann on Nov 9, 2016 8:30:56 GMT -5
Haha, are you people kidding me with level of impairment stuff? Marijuana has been around for thousands of years. prior to 1929 40% of medicine in the USA had cannabis in it. Not the same types available today. For instance: www.cnn.com/2013/08/09/health/weed-potency-levels/"Since 1972 ... the average THC content of marijuana has soared from less than 1% to 3 to 4% in the 1990s, to nearly 13% today." www.forbes.com/sites/alicegwalton/2015/03/23/pot-evolution-how-the-makeup-of-marijuana-has-changed-over-time/#7785604d5579"Marijuana has definitely evolved in the last few decades. Its potency is higher than ever: A lab in Colorado has just analyzed 600 samples of marijuana, both recreational and medical, and found that tetrahydrocannabinol (THC) content has risen markedly, whereas cannabidiol (CBD), which many say has therapeutic value, has declined." "The main finding of the new analysis was that potency has risen by a factor of three in the last few decade. “As far as potency goes, it’s been surprising how strong a lot of the marijuana is,” says researcher and study lead Andy LaFrate. “We’ve seen potency values close to 30 percent THC, which is huge.” Potency used to be around 10% or less, but it’s been bred upwards over the years, presumably because the market has demanded it." |
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Post by peppy on Nov 9, 2016 8:35:05 GMT -5
agreed, it is better. We voted a madman into the figure head office. We are going to need it.
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Post by mnholdem on Nov 9, 2016 9:39:28 GMT -5
Decriminalizing small amounts of pot in states that tend to lean liberal is one thing, proclaiming that marijuana will be the savior of MNKD is something else. Afrezza is a drug regulated by the FDA, and marijuana is still a Schedule 1 drug along with other drugs of abuse. Has anybody thought through the blowback that will result at the FDA for participation in a marijuana project, or how MNKD can even benefit from it? One of the biggest problems pot dispensaries have is that they are denied use of the banking system because the origin of their money is illegal, and they are likewise denied any deductions on their federal tax returns (i.e. they can't even deduct rent or payroll) due to the drug connection, while most illegal businesses are allowed deductions. If RLS makes milestone payments to MNKD, which will need to be in cash, how is that going to help the company if they can't deposit the money? It will take a change in federal law to alter the landscape, and that is a ways off. This is precisely why MannKind has only licensed their manufacturing technology. MannKind will not even be producing the FDKP powder under this agreement. I see your point about payments - both milestone and future royalties and it will be interesting to see how this develops. But I believe that the landscape is changing with regard to the FDA and marijuana. In fact, the FDA has a webpage devoted to this topic.
Excerpt:
The FDA has not approved marijuana as a safe and effective drug for any indication. The agency has, however, approved two drugs containing a synthetic version of a substance that is present in the marijuana plant and one other drug containing a synthetic substance that acts similarly to compounds from marijuana but is not present in marijuana. Although the FDA has not approved any drug product containing or derived from botanical marijuana, the FDA is aware that there is considerable interest in its use to attempt to treat a number of medical conditions, including, for example, glaucoma, AIDS wasting syndrome, neuropathic pain, cancer, multiple sclerosis, chemotherapy-induced nausea, and certain seizure disorders.
The FDA’s role in the regulation of drugs, including marijuana and marijuana-derived products, also includes review of applications to market drugs to determine whether proposed drug products are safe and effective for their intended indications. The FDA’s drug approval process requires that clinical trials be designed and conducted in a way that provide the agency with the necessary scientific data upon which the FDA can make its approval decisions. Without this review, the FDA cannot determine whether a drug product is safe and effective. It also cannot ensure that a drug product meets appropriate quality standards. For certain drugs that have not been approved by the FDA, such as marijuana, the lack of FDA approval and oversight means that the purity and potency of the drug may vary considerably.
As with other drugs that are not approved by the FDA, the agency works closely with the medical and patient communities, and our federal partners when necessary, to allow access to experimental treatments through the expanded access provisions described in the FDA’s statute and regulations. The FDA’s expanded access provisions are designed to facilitate the availability of investigational products to patients with serious diseases or conditions when there is no comparable or satisfactory alternative therapy available, either because the patients have exhausted treatment with or are intolerant of approved therapies, or when the patients are not eligible for an ongoing clinical trial.
As a part of this role, the FDA supports those in the medical research community who intend to study marijuana.
The FDA also supports research into the medical use of marijuana and its constituents through cooperation with other federal agencies involved in marijuana research. Conducting clinical research using marijuana involves interactions with other federal agencies:
• The FDA reviews the IND application and the research protocol submitted by the applicant.
• The Drug Enforcement Administration (DEA) reviews the registration application filed by the researcher.
• The National Institute on Drug Abuse (NIDA) within the National Institutes of Health operates pursuant to the Single Convention on Narcotic Drugs. NIDA has been designated the responsible agency to supply research-grade marijuana to researchers.
State Legislation on Marijuana
Several states have either passed laws that remove state restrictions on the medical use of marijuana and its derivatives or are considering doing so. The FDA supports researchers who conduct adequate and well-controlled clinical trials which may lead to the development of safe and effective marijuana products to treat medical conditions. We have talked to several states, including Florida, Georgia, Louisiana, New York and Pennsylvania, who are considering support for medical research of marijuana and its derivatives to ensure that their plans meet federal requirements and scientific standards.
Source: www.fda.gov/NewsEvents/PublicHealthFocus/ucm421163.htm
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Between you and me (and a few thousand ProBoard members), I am not proclaiming that "marijuana will be the savior of MNKD", as you phrase it. However, I do see RLS as a deal that could become quite lucrative in the future, if medical-grade cannabis is what we're talking about. Even that is still speculative until MannKind introduces their partner and its plans for API-TS.
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Post by novafett on Nov 9, 2016 9:53:40 GMT -5
My take on pot is anecdotal at best. As someone who smoked it on a regular basis in high school, i can tell you i went from a mildly motivated kid who was into sports, got decent (not spectacular) grades to a cloudy headed, slacker, who only wanted to party. I quit the baseball team and ended up getting an F in gym because my gym waiver (go to study hall instead) was dropped after leaving baseball midseason but i kept going to study hall even though i knew i should switch back to gym. LOL.
I recognized that I couldn't think as clearly or as quick as i once did and near the end of my Jr. beginning of my Sr. year and called it quits, cold turkey. I'm not arguing the merit of it from a medical perspective but can say from a personal use perspective it was not good for me. Others mileage may vary.
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Post by ilovekauai on Nov 9, 2016 9:59:59 GMT -5
Alcohol/pot are nonstarters for me. I quit both over 8 years ago, but do not begrudge others who want to use. It's all about personal choice to me. IMO, the whole RLS/MNKD pot thing is a bit overblown at this time. I really don't expect much there. Time will tell.
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Post by lakon on Nov 9, 2016 10:27:45 GMT -5
agreed, it is better. We voted a madman into the figure head office. We are going to need it. C'mon, everyone knows that Mad Men are better than Mad Women.  |
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