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Post by cm5 on Jul 10, 2016 18:27:39 GMT -5
And, specifically asking matt, in studying fibrosis, what consideration is given to the role of matrix metalloproteinases (MMPs) activity? For explanation, MMP's involved in pathogenesis of glomerular fibrosis (renal fibrosis) and idiopathic pulmonary fibrosis--- Also, from Wikepedia---The MMPs play an important role in tissue remodeling associated with various physiological or pathological processes such as morphogenesis, angiogenesis, tissue repair, cirrhosis, arthritis, and metastasis.
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Post by cm5 on Jul 10, 2016 18:09:53 GMT -5
Understand concerns about initiation of fibrosis, specifically asking matt, who consistently posts critical information/assessments ---what is the correlation with duration of insulin (half-life) as an initiator of steps leading to initiation of fibrosis?
In other words, referring back to another post: Increased Intrinsic Disorder Propensity in Some Insulin Analogues as a Marker of their Increased MitogenicityPlus, untreated DM Type II are clinically notorious for multiple fibrotic changes, including cataracts, small vessel disease, poor healing, hard blood draws from thick, stiff, waxy integument----
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Post by cm5 on Jul 2, 2016 11:17:17 GMT -5
Perhaps Mike already is aware, or perhaps someone has already forwarded this to him----if not, would you do this?
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Post by cm5 on Jun 25, 2016 21:56:06 GMT -5
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Post by cm5 on Jun 25, 2016 19:56:27 GMT -5
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Post by cm5 on Jun 25, 2016 18:40:06 GMT -5
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Post by cm5 on Jun 19, 2016 14:28:38 GMT -5
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Post by cm5 on Jun 14, 2016 8:45:12 GMT -5
From article above:
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Post by cm5 on Jun 12, 2016 20:49:27 GMT -5
Re: stated concerns "proving" HgbA1C, see following. Also read resources about post prandial blood sugar levels and consequent HcbA1C. And, undoubtedly, given below, studies are underway. cm5 Jun 4, 2016 8:48:59 GMT -4 cm5 said: More: Mannkind Patents 8,258,095Again, critical time to bring attention/focus to the below:
Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content
www.google.com/patents/US8258095B2
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Post by cm5 on Jun 12, 2016 20:47:47 GMT -5
Re: stated concerns "proving" HgbA1C, see following. Also read resources about post prandial blood sugar levels and consequent HcbA1C. And, undoubtedly, given below, studies are underway. More: Mannkind Patents 8,258,095 Again, critical time to bring attention/focus to the below: Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal contentwww.google.com/patents/US8258095B2
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Post by cm5 on Jun 12, 2016 16:10:04 GMT -5
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Post by cm5 on Jun 12, 2016 12:15:06 GMT -5
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Post by cm5 on Jun 12, 2016 10:55:03 GMT -5
doctor-deena.blogspot.com
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Post by cm5 on Jun 12, 2016 10:30:02 GMT -5
See this abstract, to place above in context: bmjopen.bmj.com/content/6/2/e009421.fullSafety and efficacy of insulin glargine 300 u/mL compared with other basal insulin therapies in patients with type 2 diabetes mellitus: a network meta-analysisNick Freemantle1, Engels Chou2, Christian Frois3, Daisy Zhuo3, Walter Lehmacher4, Aleksandra Vlajnic5, Hongwei Wang2, Hsing-wen Chung6, Quanwu Zhang2, Eric Wu3, Charles Gerrits2 1Department of Primary Care and Population Health, University College London, London, UK 2Global Evidence & Value Development/Health Economics & Outcomes Research, Sanofi, Bridgewater, New Jersey, USA 3Analysis Group, AG, Boston, Massachusetts, USA 4Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany 5Global Medical Affairs Diabetes, Sanofi, Bridgewater, New Jersey, USA 6TechData Service Company, LLC, King of Prussia, Pennsylvania, USA Correspondence to Dr Nick Freemantle; nicholas.freemantle@ucl.ac.uk Published 15 February 2016
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Post by cm5 on Jun 10, 2016 23:31:42 GMT -5
Understand that the image is listed on this website---
But, is there a "Why" for this particular image?
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