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Post by cm5 on Mar 4, 2017 18:21:42 GMT -5
Thought to consider: Just exactly who are the "ghost writers" for the 2017 Endo Consensus on TCD???
Unless one has been active in academic medicine, one does not realize that at least some publications about pharmaceutical agents are written/composed by a pharmaceutical company, and then handed to the stated authors, aka "Thought Leaders".
This practice for psychyotropic pharmaceuticals has been called out by Dr. David Healy.
Healy D, Cattell D (2003). "The Interface between authorship, industry and science in the domain of therapeutics". British Journal of Psychiatry. 182: 22–27.
"Pharmageddon" University of California Press(2012) ISBN 978-0-520-27098-5
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Post by cm5 on Feb 22, 2017 11:21:45 GMT -5
Well, there is one other for sure-----I think moniker is Afrezza doc----or close to that.
I am board certified in a speciality, MD, to make that clear.
I believe you are referring to Stevil as a med student-------although there were many indications (quality of posts, info in posts, constant and long frequent posts when over all there is barely time to breath in medical school) that he was really not a bona fide medical student-----that's my opinion.
I do know that there are several dermatologists in the NEC who believe in this product, and as far as I know, are still investors-----this by direct word of mouth, and statement "I don't understand why this specialty seems to get this more than others"-----from a drug rep in completely different company/product line/disease, who calls upon many specialists of all sorts----curious
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Post by cm5 on Feb 19, 2017 16:11:08 GMT -5
Words----so much fun food for thought--
Thought Leader = Group Think Leader
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Post by cm5 on Feb 19, 2017 14:18:01 GMT -5
BTW----the point of my post above is that once a physician, who gives the "canned" talks, receives just average review from attendees, said physician now on the g train for as long as one wants. Decades, if one wants. Vacation/dinner schedules are set for years to come.
So, a physician with a license and board certification and seeing patients in a certain field is really the only requirement.
And then one will have built a track record, is invited to more and more conferences. Then one is invited to give presentations at specialty meetings, which give valid Category 1 Continuing Medical Education Credits (aka CME, so many hours of such category required for maintenance of licensure, varying from state to state).
So, then one will have many CME talks to give at great venues----Hawaii, Aspen, Boston, etc etc-----and without having done a lick of ongoing real clinical or lab research.
And, the industry sponsored speaker sessions with generous stipends for non-CME dinners and such continue, as well.
Some of us weary of spending excessive dollars to go to these meetings to obtain such required CME HOURS, as we call it------hearing same ole, same ole, same ole, for the most part-----at these national and regional meetings. There is good material at these meetings----but not enough to meet the required hours.
And Standards of Care have been promulgated by above said experts.
I absolutely would do this if I really was an expert, and what I was teaching/explaining was a pharmaceutical that improves the qualities of lives on a logarithmic, if not exponential scale.
But I am neither an expert nor doing real research.
But I do know enough to post on Mannkind Proboards in support of a disruptive technology (Technosphere) and human insulin (Afrezza), and the multitude of patents, including diketopiperazine which, for instance human insulin, to pass into the alveolar capillary without damage/disruption to cellular membranes--------
Diketopiperazine is the transporter--------of targeted chemotherapy, vaccines, hormones, pain relief, on and on and on------
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Post by cm5 on Feb 19, 2017 12:59:18 GMT -5
It's been said many times to young physicians:
"Want to become an expert on a certain disease topic? Sign up to give a talk at a meeting. Over time, as you give more talks, you will be invited to present at more and more meetings. You'll be able to travel to great locations, travel/lodging/meal costs are covered, plus you will receive a stipend. At some point, if you are a minimally effective speaker, you will be invited by industry to be a 'spokes person' and even more opportunities will arise."
I wanted to see if this was really so, so I hopped on the train very a very short period of time. It is true. It was lucrative. I also had to attend private sessions held/directed by a pharmaceutical giant so that I would be "informed". I was provided with Power Point presentation, coaching on what queries to be expect/to be prepared for, what to say, what not to say---
I donated the payment for this one presentation to a responsible medical charity, and sent a letter stating that I was not interested to doing any similar activities in the future.
As an aside, I also volunteered to sit in on health care organization committee meetings for determining which new medications would be added, and most significantly, what would the organization gain from rebates from the major pharmacy benefit managers--------
Absolutely we need new and better ways to promote health and to help those who have become ill. I am not opposed to valid research and development by ethical companies, better ways of approval for medication, and helping people living better lives.
I learned all I needed from these two experiences.
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Post by cm5 on Feb 11, 2017 17:36:41 GMT -5
Concur absolutely with the above.
Every single patient/family member has asked me to write down the name of Afrezza when I bring it up.
So, I write down Afrezza, write search the Mannkind site for patient assistance, write search for videos about Afrezza.
BTW, I bring up Afrezza only when the patient or family voice frustration with their medications, costs, side effects.
More than a few have switched to different endocrinologists or have found new PCP's.
I want the best for the people I care for. I would be remiss if I did not do this-----
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Post by cm5 on Jan 17, 2017 7:42:12 GMT -5
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Post by cm5 on Jan 2, 2017 7:25:08 GMT -5
Game changer, life saving.
Thank You, Mango, for this post, the posts on Allecures and other innovative biotech companies associated with/developed by Alfred Mann.
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Post by cm5 on Oct 9, 2016 10:17:32 GMT -5
More---- September 5, 2016 at 12:53am mango
"Thought I would pop in and tell everyone Andrea Leone-Bay is back."
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Post by cm5 on Oct 9, 2016 10:03:00 GMT -5
Time to refresh focus on the fact that Alfred Mann's wisdom, brilliance about inhaled monomeric human insulin, Afrezza, with Technosphere will exponentially improve world health, while reducing health care costs.We continue to be distracted by the posts of naysayers/fudsters as well as inappropriately impatient about the realities of navigating the shark filled shallows and depths of the choppy seas of typical regulatory oversight as well as the "random" rogue wave created by insider fraud/hedge fund/algorithm/manipulated "market maker" churning, all of which is based upon greed and fear of loss of market/income/power/control. There have been many fine posts, in particular by mnholdem and peppy, but now is good time to point out the fundamentals yet again why we remain driven to see Mannkind become the game changer. Take the long view, as did Alfred Mann. Alfred Mann was the beyond brilliant man who could see the entire elephant from above, in it's habitat and it's place on our beautiful blue planet, while the blind fumblers,small minded and greedy play games with lives stalling the inevitable success of Mannkind, for short term amoral gain counting coin. Read this Mannkind patent again carefully. If no time/interest in detailed reading, just go to the highlighted areas for overall view. Go to the patent link to find the references. Method of reducing serum proinsulin levels in type 2 diabetics US 20050153874 A1ABSTRACT Methods are provided for reducing serum proinsulin levels, lessening post-prandial pancreatic stress, and reducing risk factors for atherosclerosis in subjects with diabetes mellitus, type 2. The method includes administration of insulin in a manner that mimics the meal-related first phase insulin response, using a dose sufficient to reduce serum levels of proinsulin. In some embodiments of the method insulin administration is commenced early in the course of the disease. Mimicking first phase kinetics, peak serum insulin levels can be reached within about 18 minutes of administration. In increasingly preferred embodiments peak serum insulin levels can be reached within about 15, 12, or 10 minutes of administration. Serum insulin levels return to baseline within about two hours of administration.
Publication date Jul 14, 2005 www.google.com/patents/US20050153874Some thoughts---was Sanofi CEO Brandicourt not brilliant enough to see the big picture how Afrezza combined with Lantus could have been the big winner? Was he pressured by the board to keep French labor somewhat content (just look up where Sanofi ranks in France in terms of employement). Insider corruption between employees of regulatory agencies and the "money changers"?
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Post by cm5 on Oct 9, 2016 9:08:27 GMT -5
I am reposting the below, because, long and short, we are dancing around the screaming need for inhalable epi via Technosphere, while Heather Bresch/other corporate office tier collect millions putting generic "auto-injections" of epinephrine in fancy plastic cases and bright yellow boxes-------- Given that I recently had a horrific anaphylaxis experience, from which I am finally just about back to normal, I state emphatically that having had Mannkind's Technosphere with inhalable epinephrine, which I could have reused many times over a 5 days of recurring anaphylaxis from one single ingestion of one single food item, that was nearly fatal, I would not have missed more than a month of my life/work/research. Not only is there an emergent, ongoing, continual need for Mannkind's inhalable epinephrine for prevention/control of anaphylaxis---We all need Technosphere for dry particle inhalation of allergens to induce tolerance to the high risk allergens for which no good/safe/accepted desensitization process currently exists.
The major antigens, among others not listed, that are not now safely addressed with existing methods:
Peanuts/Nuts
Nuts
Shellfish
Eggs
Soy
Eposphere - A Key to Technosphere+Epinephrine Aug 7, 2016 at 1:54pm mnkd.proboards.com/post/75038
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Post by cm5 on Oct 9, 2016 8:52:08 GMT -5
Re: Tamarisk, all associated websites unavailable/or down this am. Re: Tamarisk's oral nanoparticle insulin, quoted as "holy grail" by principals elsewhere, see, in this 2012 article www.in-pharmatechnologist.com/Drug-Delivery/Tamarisk-Technologies-claims-to-have-solved-the-oral-insulin-puzzleBut, please recall, Mannkind's patent re: oral DKFP insulin, and other relevant patents: And, a reminder about the inherent safety of diketopiperazine, before the alarmists/fudsters start posting--- Deketopiperazine is in our food, essential component of "taste", in particular in cocoa, the Maillard reaction----ie, browning, carmelization, all the wonderful tastes/smell of real food.
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Post by cm5 on Sept 6, 2016 19:55:37 GMT -5
I remain curious----why do agedhippie, matt, now sophie. etc all reply in concert, and to date, have never posted a single reference to a link, an article, a source for verification?
Just wondering, saying---
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Post by cm5 on Sept 6, 2016 19:39:39 GMT -5
Probably the overall risks of degenerative disease, dementia, and cancer from the ongoing burden of unrelieved, constant inflammation are magnitudes exponentially higher relative to the very time limited in and out of the lungs Afrezza in Mannkind's Technosphere-- See this review, which liane has posted, www.academia.edu/3528846/TECHNOSPHERE_INSULIN_INHALER_A_REVIEWAnd, see this study: Insulin lung deposition and clearance following Technosphere® insulin inhalation powder administration.Pharm Res. 2011 Sep;28(9):2157-64. doi: 10.1007/s11095-011-0443-4. Epub 2011 Apr 14. www.ncbi.nlm.nih.gov/pubmed/21491144
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Post by cm5 on Sept 4, 2016 14:03:06 GMT -5
Thank you, cjm18, for posting link to excellent article about how to eat healthfully, reduce risks. I add the following: AGE's Advanced Glycation End Products are just as important as the Glycemic Index:
Advanced Glycation End Products By Lori Zanteson Today’s Dietitian Vol. 16 No. 3 P. 10www.todaysdietitian.com/newarchives/030314p10.shtmlThe Trinity---Low Glycemic Index, Low AGE's, + AfrezzaJust think how public health deterioration could reverse if everyone appreciated, understood, and had access to the three components----- But, society as a whole has to do something about access to good basic foods, and to make certain that everyone has the time for all of the trinity--plus walking, plus some kind of exercise---not work shift micromanagement, as initiated and perpetuated by Starbucks, a corporation that does not hesitate to imply moral superiority. Very curious.
Just imagine the possibilities.
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