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Post by mango on Jun 13, 2017 12:28:24 GMT -5
Diketopiperazine salts for drug delivery and related methods
Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
Type: Grant
Filed: January 8, 2016
Date of Patent: June 13, 2017
Assignee: MannKind Corporation
Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
patents.justia.com/patent/9675674
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Post by liane on Jun 13, 2017 13:25:11 GMT -5
mango - Do we really need a new thread for every patent? I am renaming this thread "MNKD Patents". How about you post any new patents here. If I feel really ambitious and have loads of free time, I may move some of the old patent threads here - but it may be a while.
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Post by mango on Jun 13, 2017 14:03:06 GMT -5
mango - Do we really need a new thread for every patent? I am renaming this thread "MNKD Patents". How about you post any new patents here. If I feel really ambitious and have loads of free time, I may move some of the old patent threads here - but it may be a while. Sorry  |
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Post by babaoriley on Jun 13, 2017 15:58:31 GMT -5
Mommy liane really nailed you, mango! A little in terrorem never hurt a message board!  |
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Post by liane on Jun 13, 2017 16:09:24 GMT -5
There goes baba throwing around those fancy Latin phrases |
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Post by sayhey24 on Jun 13, 2017 16:30:03 GMT -5
Andrea Leone-Bay where is the CBD?
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Post by mango on Jun 14, 2017 2:18:59 GMT -5
Mommy liane really nailed you, mango! A little in terrorem never hurt a message board! Argumentum ad baculum |
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Post by mnholdem on Jun 14, 2017 6:30:59 GMT -5
There goes baba throwing around those fancy Latin phrases Liane, do you think we should consider creating a thread just for baba when he has these grammatical outbursts? The Latin term vox populi is "the voice of the people," so perhaps a thread with the title vox baba ? |
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Post by mango on Jun 14, 2017 9:00:04 GMT -5
Andrea Leone-Bay where is the CBD? Cannabinoids is mentioned three times in the patent. |
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Post by peppy on Jun 14, 2017 9:24:10 GMT -5
Andrea Leone-Bay where is the CBD? Cannabinoids is mentioned three times in the patent. Mango since you read it and understand what are reading, "Diketopiperazine salts for drug delivery and related methods " is it buffers and a buffering system?
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Post by mango on Jul 5, 2017 22:49:14 GMT -5
New MannKind Granted Patent 7/4/17 IRE-1α inhibitors Abstract: Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies. Type: Grant Filed: January 12, 2015 Date of Patent: July 4, 2017 Assignee: MannKind Corporation Inventors: Qingping Zeng, Andras Toro, John Bruce Patterson, Warren Stanfield Wade, Zoltan Zubovics, Yun Yang, Zhipeng Wu patents.justia.com/patent/9693992 |
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Post by mango on Jul 10, 2017 7:01:52 GMT -5
Three New International MannKind Patents 1. BLISTERPAKNING TIL FARMACEUTISKE CYLINDERAMPULLERApplication Date: 30.03.2012 Publication Date: 03.07.2017 Grant Date: 03.07.2017 Applicants: MannKind Corporation Inventors: BERGEY, Michael, S. Title: (DA) BLISTERPAKNING TIL FARMACEUTISKE CYLINDERAMPULLER Abstract: (EN) A blister packaging for a pharmaceutical cartridge or capsule and methods of forming same are disclosed. patentscope.wipo.int/search/en/detail.jsf?docId=DK2004798232. Use of Ultrarapid Acting InsulinApplication Date: 27.03.2015 Publication Date: 06.07.2017 Applicants: MannKind Corporation Inventors: Anders Hasager Boss, Richard Petrucci Title: (EN) Use of Ultrarapid Acting Insulin Abstract: (EN) Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day. patentscope.wipo.int/search/en/detail.jsf?docId=US2004693113. DIKETOPIPERAZINE MICROPARTICLES WITH DEFINED SPECIFIC SURFACE AREASApplication Date: 17.03.2017 Publication Date: 06.07.2017 Applicants: MannKind Corporation Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin, John J. Freeman, JR. Title: (EN) DIKETOPIPERAZINE MICROPARTICLES WITH DEFINED SPECIFIC SURFACE AREAS Abstract: (EN) Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin. patentscope.wipo.int/search/en/detail.jsf?docId=US200469214 |
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Post by mango on Jul 11, 2017 13:54:46 GMT -5
New Granted MannKind Patent 7/11/2017 Inhalation apparatusAbstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion. Type: Grant Filed: June 12, 2014 Date of Patent: July 11, 2017 Assignee: MannKind Corporation Inventors: Trent Poole, Solomon S. Steiner Claims3. The inhaler of claim 2, wherein the dry powder within the chamber comprises a bioactive molecule. 4. The inhaler of claim 2, wherein the dry powder comprises atropine, penicillin, doxycycline, ciproflaxin or a fluoroquinolone. 5. The inhaler of claim 4, wherein the dry powder further comprises a diketopiperazine. 6. The inhaler of claim 5 wherein the dry powder comprises atropine. 7. The inhaler of claim 5 wherein the dry powder comprises penicillin. 8. The inhaler of claim 5 wherein the dry powder comprises doxycycline. 9. The inhaler of claim 5 wherein the dry powder comprises ciproflaxin. 10. The inhaler of claim 5 wherein the dry powder comprises a fluoroquinolone. patents.justia.com/patent/9700690• Picture of the Inhalation apparatus:  |
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Post by victoria on Jul 11, 2017 14:51:19 GMT -5
New Granted MannKind Patent 7/11/2017 Inhalation apparatusAbstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion. Type: Grant Filed: June 12, 2014 Date of Patent: July 11, 2017 Assignee: MannKind Corporation Inventors: Trent Poole, Solomon S. Steiner Claims3. The inhaler of claim 2, wherein the dry powder within the chamber comprises a bioactive molecule. 4. The inhaler of claim 2, wherein the dry powder comprises atropine, penicillin, doxycycline, ciproflaxin or a fluoroquinolone. 5. The inhaler of claim 4, wherein the dry powder further comprises a diketopiperazine. 6. The inhaler of claim 5 wherein the dry powder comprises atropine. 7. The inhaler of claim 5 wherein the dry powder comprises penicillin. 8. The inhaler of claim 5 wherein the dry powder comprises doxycycline. 9. The inhaler of claim 5 wherein the dry powder comprises ciproflaxin. 10. The inhaler of claim 5 wherein the dry powder comprises a fluoroquinolone. patents.justia.com/patent/9700690• Picture of the Inhalation apparatus: Ahh, now I like this one. This is not the usual variation on a theme. Looks like emergency use inhaler for acute situations. Nice. |
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Post by mango on Jul 11, 2017 19:33:17 GMT -5
New Granted MannKind Patent 7/11/2017 Inhalation apparatusAbstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion. Type: Grant Filed: June 12, 2014 Date of Patent: July 11, 2017 Assignee: MannKind Corporation Inventors: Trent Poole, Solomon S. Steiner Claims3. The inhaler of claim 2, wherein the dry powder within the chamber comprises a bioactive molecule. 4. The inhaler of claim 2, wherein the dry powder comprises atropine, penicillin, doxycycline, ciproflaxin or a fluoroquinolone. 5. The inhaler of claim 4, wherein the dry powder further comprises a diketopiperazine. 6. The inhaler of claim 5 wherein the dry powder comprises atropine. 7. The inhaler of claim 5 wherein the dry powder comprises penicillin. 8. The inhaler of claim 5 wherein the dry powder comprises doxycycline. 9. The inhaler of claim 5 wherein the dry powder comprises ciproflaxin. 10. The inhaler of claim 5 wherein the dry powder comprises a fluoroquinolone. patents.justia.com/patent/9700690• Picture of the Inhalation apparatus: Ahh, now I like this one. This is not the usual variation on a theme. Looks like emergency use inhaler for acute situations. Nice. Nice X 2. This patent is essentially the foundation of MannKind and Technosphere. This is military technology and also emergency tech and for rapid emergency civilian use. The patent, in the whole picture view kinda perspective, mimics that first original patent (of Technosphere) by Pharmaceutical Discovery Corp that Al acquired and subsequently filed patent under MannKind after doing which gave birth—Afrezza. This is essential for military and first responders, like you mentioned, but also for civilians. mango remembers reading that Al and KK were somehow connected to the military. mango also remembers reading and seeing the POTUS support the military more than any president he has had to personally experience (mango is young). I am thinking of the VA contract. I am thinking of how TechnoVax just this past month received HUGE positive results and publicity for their pre-clinical Zika virus results. I am thinking about where ( Brazil) Zika effected the worst. I am thinking how Jose Galarza of TechnoVax is from South America. Disclosure: mango is a dreamer but he is also smarter than Spencer Osborne. |
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