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Post by spiro on Apr 10, 2015 10:32:29 GMT -5
Spiro has always been a big Gomnkd fan, until the last couple of days, LOL, just kidding. Spiro still likes Gomnkd, but he just can't figure out all that financial mumbo jumbo that Gomnkd has been posting recently.
Spiro here
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Post by spiro on Apr 10, 2015 9:30:49 GMT -5
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Post by spiro on Apr 10, 2015 9:14:41 GMT -5
Some people need to read this again. I think we could probably add quite a few more numbers to this list. Spiro can personally confirm quite a few of these comments.
Spiro here
seekingalpha.com/instablog/6050591-us-investor/2550421-20-reasons-why-mannkinds-afrezza-is-superior-to-novolog-humalog
20 Reasons Why Mannkind's Afrezza Is Superior To Novolog/Humalog 5 comments Jan 7, 2014 11:11 AM | about stocks: LLY, NVO, MNKD
Mannkind's (MNKD) lead drug Afrezza is nearing the PDUFA date of 15-Apr-2014. Afrezza is an inhaled insulin for use during meal times. Mannkind has submitted the NDA for the 3rd time. Here are the 20 reasons why Afrezza is superior to its nearest competitors Novolog/Humalog. Novolog is marketed by Novo Nordisk (NVO) and Humalog by Eli Lily (LLY).
1. Afrezza is ultra-rapid acting insulin with a pharmacokinetic profile that mimics endogenous secretion of insulin. In plain English, Afrezza works like body's natural secretion of insulin by pancreas during meal time. Novolog/Humalog are called rapid acting analogues and don't even come close. The reason for the ultra-rapid acting is due to the fact that Afrezza has monomeric insulin.
2. Afrezza is delivered by a sleek device that is discreet, portable and easy to use. Novolog & Humalog are delivered by injections. The inhaler is disposable.
3. Afrezza has lower post-prandial glucose excursions. Hence it results in lower long term diabetic complications.
4. Afrezza requires little or no titration compared to Novolog/Humalog. There are no correctional dosages needed. The accurate card counting would be a thing of the past.
5. Afrezza requires less blood glucose (BG) level testing. This is one of the major pain points of diabetics. A typical diabetic needs one or more correctional insulin shots after a heavy meal and 3-4 times BG testing.
6. Afrezza reduces the stress on pancreas as it takes the load off the pancreas. The hyperglycemia is less pronounced for Afrezza users. (see pg. 7). Brief glucose excursions outside the normal physiological range are especially damaging to β-cells. Afrezza helps the pancreas live longer.
7. Afrezza patients will show better compliance. This reduces the long term diabetic costs. Recent survey indicates that 1/3rd of patients fail to take insulin as prescribed.
8. The physicians can initiate insulin therapy earlier with Afrezza.
9. No injection site complications like lipodystrophy, pain, redness, irritation and no need to keep track of injection sites for rotation.
10. No post meal snacking and weight gain with Afrezza. The post meal snacking is a feature of Novolog/Humalog that causes hypos due to long tail.
11. Afrezza shows much lower incidences of hypoglycemia. According to this article, One in 20 people (an estimated 2-4 percent and 6 percent in patients younger than 40 years old) will perish from severe hypoglycemia.
12. Afrezza offers lower costs in the long run if we consider the reduced BG tests, no correctional dosages, better compliance and reduced long term complications due to lack of hyperglycemia.
13. The Griffin research mentioned earlier says that prophylactic use of Afrezza prevents type 2 diabetes. It is a hard sell to use deploy prophylactic use of Novolog/Humalog
14. Survey of patients who participated in Afrezza trials reported higher satisfaction rates
15. Anecdotal evidence from trial patients who used Afrezza reported better HbA1C. In some recent trials, Mannkind was able to show superiority in A1C. You can read more about the background on A1C in this article as well.
16. Due to superior kinetics, Afrezza shuts off the hepatic secretion of glucose. The body needs less insulin during meal time.
17. Patients need less training, Afrezza is easier to learn and use
18. Obese patients will show better glucose clearance with Afrezza. Children who take meal time insulin will be less traumatized. The FDA has approved pediatric trials for Afrezza.
19. Afrezza is a God sent for needle phobic patients.
20. Afrezza is easier to use for visually impaired patients and for patients with various disabilities.
Afrezza, if approved will give the current rapid acting analogues a run for its money. Al Mann, the CEO of Mannkind corp says that Afrezza will be the greatest medical product in history. The potential market size is just enormous. According to the recent Canaccord presentation, the potential patient population in U.S. alone includes
· 3.2 million on prandial insulin
· 1.9 million on basal insulin as the only insulin
· 12.6 million on oral agents alone
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Post by spiro on Apr 9, 2015 16:40:48 GMT -5
One glazed Krispy Creme donut has 22 grams of carbs. Spiro used to snack on 4 of them at a time. 4 donut holes makes a lot better sense now.
Spiro here, a soon to be reformed fatso.
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Post by spiro on Apr 8, 2015 20:20:50 GMT -5
thekindaguyiyam,
The Dexilant costs the insurance company $205/month x 12 or $2460. Afrezza will be $235 x12 or $2820. So without counting my other 3 generic drugs, Spiro is already $1280 into the doughnut hole. Spiro wants to know if they sell glazed donuts in Siberia?
Spiro here
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Post by spiro on Apr 8, 2015 20:06:37 GMT -5
After the doughnut hole is reached, the participant pays 45% of the plans cost for brand name and 65% for generic until your costs total $4700, which is the end of the coverage gap. Spiro has no clue what all this means. He thinks the insurance companies are more like a black hole, sucking up all of his money. it's so nice of them to call this a puny doughnut hole.
Spiro here
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Post by spiro on Apr 8, 2015 18:06:43 GMT -5
Spiro got a call from his Health Insurance Company today and a guy told Spiro that because of Afrezza and Dexilant, he was going to fall into the doughnut hole by the end of the year. Thinking that it was some kind of trick insurance question, Spiro immediately told the guy, that he hasn't eaten a doughnut since he started using Afrezza. He then told Spiro that he needed to immediately have his doctor change all of his scripts into 90 day scripts, which could reduce the cost of the Donut hole later in the year. Spiro was now in donuts mode and asked the insurance guy, if this applied to both glazed donuts and chocolate donuts. He said that Spiro would reach the donut hole when he reached $4000. Let's see, that could buy around 500 dozen boxes of donuts. At this point in the conversation, it finally became apparent to Spiro, that donut holes could have an impact on TRx counts for Afrezza. These damn insurance companies sure know how to ruin a perfectly good snack.
Spiro here
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Post by spiro on Apr 8, 2015 16:43:53 GMT -5
Spiro thinks the pitfalls of diabetics not using Afrezza have been showing up for a long time now. Spiro also thinks that the parallels of some posters to OPC are starting to show. This need to be 100% correct on every issue and always have the last word has not been the norm for this board.
After all the Baklava talk, that Malomar tasted lousy after dinner tonight.
Spiro here
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Post by spiro on Apr 8, 2015 15:27:04 GMT -5
Scotta,
Baklava could possibly be the worst food that Spiro could get his hands on. Spiro doesn't just eat a 1 inch by 1 inch piece of homemade Baklava. They are at least 3 inch by 3 inch and probably contain 3 times more carbs than this chart. Spiro would eat at least 2 pieces.
Nutrition summary: Calories 428 Fat 29.0 Carbs 37.62g Protein 6.7g
There are 428 calories in 100 grams of Baklava.
Calorie breakdown: 60% fat, 34% carbs, 6% protein.
Other Common Serving Sizes:
Serving Size Calories 1 cubic inch 56 1 oz 121 1 piece (2" x 2" x 1-1/2") 334 100 g 428
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Post by spiro on Apr 8, 2015 14:03:28 GMT -5
Spiro is too old not to have the patience it will take to stay long MNKD. But of course it helps to see this very morning. Without patience, some people would have quit after a week, expecting better results.
Date Fasting BG Notes 2/26/15 134 2/27/15 135 Started Afrezza at breakfast 2/28/15 131 3/1/15 119 3/2/15 115 3/3/15 114 3/4/15 113 3/5/15 100 3/6/15 101 3/7/15 116 3/8/15 105 3/9/15 99 3/10/15 108 3/11/15 94 3/12/15 100 3/13/15 93 3/14/15 106 3/15/15 97 3/16/15 104 3/17/15 94 3/18/15 99 3/19/15 88 3/20/15 98 3/21/15 95 3/22/15 95 3/23/15 88 3/24/15 90 3/25/15 91 3/26/15 94 3/27/15 97 3/28/15 90 3/29/15 95 3/30/15 98 3/31/15 89 4/1/15 98 4/2/15 100 4/3/15 88 4/4/15 93 4/5/15 95 4/6/15 90 4/7/15 94 4/8/15 91
BTW, 2 hours after a nice portion of Lamb, potatoes and Greek olives for lunch, Spiro was back down to 89. Spiro says, stop the B.S. and give Sanofi and MNKD some time to get their plan executed.
Spiro here
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Post by spiro on Apr 6, 2015 11:53:53 GMT -5
Spiro and Ashiwi were all set to go to the annual meeting until they heard that Baba will be there, hugging everybody while leading the group singing Kumbaya.
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Post by spiro on Apr 6, 2015 8:21:57 GMT -5
Come on guys, 1100 members and no one has anything to say? OK, Liane is going to delete this thread real fats.
Spiro here
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Post by spiro on Apr 4, 2015 12:42:40 GMT -5
Papi,
Thanks for the update. It took me about 7-10 days before I noticed my FBG got consistently below 100. Hopefully, you will be able to figure out what adjustments it will take to get better numbers. I wonder if dropping the Actos has made it a little tougher for Afrezza to kick in? I am sorry that I can't provide any suggestions. I have been making a very serious effort to walk at least 5 times a week and cut down on carb intake. That for sure has helped. But if I cheat, I will still get those post meal highs, they just don't last as long as before.
Spiro here
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Post by spiro on Apr 2, 2015 11:18:02 GMT -5
100 FG before breakfast, sausage biscuit, strawberries and blueberries.
149 1 hr
96 2 hr, this is the quickest recovery noted so far
82 3 hr
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Post by spiro on Apr 2, 2015 10:31:06 GMT -5
SBS,
100 FG before breakfast, sausage biscuit, strawberries and blueberries.
149 1 hr
96 2 hr, this is the quickest recovery noted so far
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