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Post by peppy on Jan 10, 2021 10:19:14 GMT -5
“Your ultimate success or failure depends on your ability to ignore the worries of the world long enough to allow your investments to succeed. It isn’t the head but the stomach that determines the fate of the stock-picker.” –Peter Lynch Too bad "long enough" can't be quantified  perhaps a pandemic that has taken 372,651 documented American lives is long enough? Perhaps a vaccine that requires - 93 degrees F is long enough? A failure of our medical systems is long enough? Vaccines given out at pharmacy retail centers and grocery stores? Hospitals discharging to rehab (Nursing homes) is long enough? Perhaps refrigerated trucks to hold the bodies is long enough? Hospitals and Hospital employees over whelmed and dying is long enough? Perhaps an undercount of oxygen condensers is long enough? Don't we see people carrying around oxygen condensers and walking around the groceries with nasal cannulas? Perhaps a 7 trillion dollar deficit is long enough? Or perhaps this was the plan? |
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Post by Chris-C on Jan 10, 2021 11:42:26 GMT -5
“Your ultimate success or failure depends on your ability to ignore the worries of the world long enough to allow your investments to succeed. It isn’t the head but the stomach that determines the fate of the stock-picker.” –Peter Lynch Too bad "long enough" can't be quantified Akemp3000: Thanks for that great quote by Lynch! I’ll tape it to my computer. That, my several failed personal experiences of selling too soon, and Nate Piles’ unwavering belief in the company “may” help keep me out of trouble. I’ve shown myself capable of some bonehead plays over time. But I look to MNKD to help me prove to myself that there IS a path to redemption. I want my next big challenge to be prudently taking profits when the company’s deserved success finally begins to arrive in the form of steadily growing net positive revenue streams, promising partnerships, and no debt. In other words, I’d love to test my ability to struggle with the pitfalls of success.😁 |
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Post by Chris-C on Jan 11, 2021 18:00:36 GMT -5
I try to follow the epidemiology of COVID19 pretty closely. The dramatic surge we are seeing in the USA now is probably a combination of spread following holiday travel and social events and will soon be accelerated by the more active presence of the UK Variant, which is estimated to be about .50 more infectious. One current speculation is that the virus mutated to make its protein spikes "Stickier" to penetrate cells in the upper respiratory system and thus replicate more efficiently (aka faster). But the larger worry at the moment is a study in Italy that examined the South African variant in vitro, exposing it to plasma containing COV-2 antibodies. The mutated virus had the capacity to escape, leading the lab to recommend further vaccine development to confer immunity in the face of these mutations.
Work is still preliminary. But I have a feeling that our current inability to get ahead of this virus through public health measures makes it more likely that further variants will evolve to challenge our incompetent response to controlling it. We need more testing of all kinds, we need more social compliance by the population and we need faster vaccine distribution. Right now, we are losing this battle, and we need to get a heck of a lot more organized and serious if we are to get ahead of it. Heck, the messaging around appropriate behaviors following vaccination should be to continue Public Health protocols until the all clear is sounded. Some evidence of coordination and some consistent messaging around vaccinations generally would be a great start for organizing a winning strategy at containing this global threat. I hope this is wrong, but I think we will reach 500K deaths in the US by Summer. The struggle will be to keep the health system from collapsing.
In my mind, for lots of reasons, (distribution, self administration, storage, etc) an inhaled vaccine might very well be part of the longer term solution. So, IMO, MNKD as a player in the pandemic vaccination effort is still very much a possibility.
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Post by goyocafe on Jan 12, 2021 13:43:01 GMT -5
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Post by goyocafe on Jan 12, 2021 18:08:37 GMT -5
Unfortunately, the article doesn’t offer much hope of Pfizer working on an inhaled vaccine. They seem focused on bulk powder and reconstitution at destination facilities. Oh well. |
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Post by goyocafe on Jan 26, 2021 7:56:58 GMT -5
Unfortunately, the article doesn’t offer much hope of Pfizer working on an inhaled vaccine. They seem focused on bulk powder and reconstitution at destination facilities. Oh well. I wonder if there is something about dry powder inhaled vaccines that makes this concept less appealing to big pharma. So far all discussion I’ve found on the dry powder subject point to a process that involves reconstitution at the point of administration. Pfizer for sure seems pointed in that direction. Arcturus seems pointed in that direction, and Ziccum doesn’t mention inhalation as part of its dry powder solution. TFFP seems focused on inhalation, but nothing specific about them working with anyone on a solution. They pumped their stock price with a speculative article last fall that suggested they might be working with Pfizer, but the information about Pfizer reconstituting dry powder seems to suggest there is nothing there either. With all of the debate and confusion with distribution of vaccines to administration centers, and the lack of human resources to assist with the administration of the vaccines, you’d think the idea of directly mailing vaccines to residents, and/or people just lining up and taking a breath at a vaccination center would significantly reduce administration costs and complexity. I have to wonder why inhalation of dry powder vaccines seems less desirable than reconstituting dry powder so that it can be injected? Is it dosing accuracy, lack of study data (and the expense of producing that data), or something else that seems to keep this concept from taking hold? |
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Post by prcgorman2 on Jan 26, 2021 8:03:29 GMT -5
Good questions. I understand that caution with respect to possible strong allergic reactions is an important reason for wanting administration to be in a clinical environment. Even so, the whole world needs vaccine and making clinical environments available everywhere can be problematic, and I think the idea of small disposable one-dose inhalers has enough appeal to warrant answers to your questions.
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Post by markado on Jan 26, 2021 9:11:27 GMT -5
Good questions. I understand that caution with respect to possible strong allergic reactions is an important reason for wanting administration to be in a clinical environment. Even so, the whole world needs vaccine and making clinical environments available everywhere can be problematic, and I think the idea of small disposable one-dose inhalers has enough appeal to warrant answers to your questions. Imagine, sending X doses of single-dose inhalable vaccine and y doses of inhalable epinephrine, where y is a fraction of x, to mitigate any strong allergic reactions. For those with knowm severe allergies, they are delivered 1:1. Not perfect, but potentially highly mitigating for more rural and remote innoculation programs. |
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Post by peppy on Jan 26, 2021 9:23:48 GMT -5
One more thing.
It is conjecture on my part. however,
With a technosphere inhaled delivery, would less of a dose be required? Because the delivery would be right into the blood stream and the lymphatic system, rather than a slow creep?
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Post by wesnigon on Jan 26, 2021 9:51:28 GMT -5
One more thing. It is conjecture on my part. however, With a technosphere inhaled delivery, would less of a dose be required? Because the delivery would be right into the blood stream and the lymphatic system, rather than a slow creep? The vials currently contain 5-6 IM doses. I would anticipate inhaled dosing would need to go through regulatory and efficacy protocols, but yes, less could be required. |
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Post by morfu on Jan 26, 2021 10:34:15 GMT -5
One more thing. It is conjecture on my part. however, With a technosphere inhaled delivery, would less of a dose be required? Because the delivery would be right into the blood stream and the lymphatic system, rather than a slow creep? The vials currently contain 5-6 IM doses. I would anticipate inhaled dosing would need to go through regulatory and efficacy protocols, but yes, less could be required. I thought at least for Insulin the amount used in Technosphere was higher in comparison. Regardless, I heard the opinion yesterday from a Nurse, that she expects the Corona vaccinations become an annual thing like flu shots. Not sure about the scientific base of that claim, but if true I and probably most people on this planet have a personal stake in this development.. not that I am afraid of needles, but if I have a choice, I would always use an alternative!
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Post by peppy on Jan 26, 2021 10:47:19 GMT -5
The vials currently contain 5-6 IM doses. I would anticipate inhaled dosing would need to go through regulatory and efficacy protocols, but yes, less could be required. I thought at least for Insulin the amount used in Technosphere was higher in comparison. Regardless, I heard the opinion yesterday from a Nurse, that she expects the Corona vaccinations become an annual thing like flu shots. Not sure about the scientific base of that claim, but if true I and probably most people on this planet have a personal stake in this development.. not that I am afraid of needles, but if I have a choice, I would always use an alternative!
Vaccine, The week in Virology, is thinking every three years for boosters. The reason would be, if we actually wanted to vaccinate places where there are not refrigerated systems. It may however be more like cowboys and Indians, and we know what happened to the Indians. Have you seen the color and age as well as allegiances our power brokers have? They do not like loosing or sharing power. Insulin, technosphere more like IV insulin. it needs to get to the cells. Vaccines need to get into the lymphatic system. ? |
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Post by letitride on Jan 26, 2021 23:25:31 GMT -5
Seems a time has come for some type of dry powder vaccine with a mucosal application but yet with the technology being present the use is non existent. A major part of the population is still squabbling over safety of our current vaccine applications. Who knows with a few hundred million deaths in short order this whole conversation may become moot and everyone will take what ever they can get after all the side affects of a vaccine are far better than the side affects of a ventilator.
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Post by longliner on Jan 27, 2021 1:51:40 GMT -5
Seems a time has come for some type of dry powder vaccine with a mucosal application but yet with the technology being present the use is non existent. A major part of the population is still squabbling over safety of our current vaccine applications. Who knows with a few hundred million deaths in short order this whole conversation may become moot and everyone will take what ever they can get after all the side affects of a vaccine are far better than the side affects of a ventilator. And we better get on it!! |
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