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Post by spiro on Oct 29, 2015 10:57:56 GMT -5
Blindhog,
Spiro keeps telling himself the same same. If someone loses patience and sells their MNKD shares, then they are definitely not Afrezza users like we are. But knowing this isn't making Spiro feel any better about his investment. About 100,000 more Afrezza users would make Spiro feel a lot better.
Spiro here, FBG 100 today, too many chocolate covered donuts yesterday, Geez, Afrezza makes it so simple to control Blood Glucose.
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Post by spiro on Oct 24, 2015 23:02:14 GMT -5
suebeeee1,
Wow, great news, more proof that Afrezza is a great prandial insulin. blind hog, you are next up.
Spiro here
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Post by spiro on Oct 22, 2015 18:39:23 GMT -5
Spiro has been hiding out 4300 feet high in his North Carolina Mountain home. Spiro's internet service/modem/router has been pathetic. It has crashed more times than the the number of posts he has not read during the past 2 weeks. He has spent over 4 hours talking to various people in India without too much success. Mrs. Spiro has now accused Spiro of having a slight India accent now. After coming to the NC mountains for over 27 years, Mr. and Mrs. Spiro spotted their first bear yesterday. Spiro is not sure how to interpret the meaning of this bear sighting. And then to complicate matters, Spiro just saw 3 deer about 100 yards from his home. The deer were being chased by about 100 chipmunks. Spiro's dog has been unsuccessfully trying to catch a chipmunk for 2 weeks. The chipmunks remind Spiro of the MNKD shorts, they are everywhere. It's amazing how they dart in front of cars, but you never see a dead one in the road. Then again, Spiro has never seen a dead short yet either. Spiro hopes he sees a dead short, before a dead chipmunk. Spiro here, get ready to sell, Spiro will be home on Sunday Attachment DeletedAttachment Deleted
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Post by spiro on Oct 2, 2015 19:35:46 GMT -5
tayl5,
Spiro doesn't know too much about that chasm thing. This technologist, visionary and pragmatist stuff is too complicated for Spiro to figure out. Spiro believes that it is much less complicated. He believes we have riders ( Afrezza users ) and Donkeys ( Endo's ). Everybody knows that some Donkeys are easy to teach and accept training quickly. They are the smart Donkeys. Now, the other Donkeys are very stubborn and refuse to cooperate and are very difficult to train. They are the stupid Donkeys. Spiro believes that at the present moment, most Endo's are stupid Donkeys.
Spiro here, hoping that PCP's are Horses, because they are not as stubborn as Donkeys
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Post by spiro on Sept 25, 2015 15:11:16 GMT -5
Spiro and Zieg were talking MNKD at lunch today.
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Post by spiro on Sept 21, 2015 11:35:15 GMT -5
Spiro found out that Baba was in Boston, trying to infiltrate the Danbury facility.
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Post by spiro on Sept 19, 2015 19:23:52 GMT -5
Blindhog, nice post. Any type 2 with an A1c of 6.9 or higher has an average BG over 151. It is such a no brainer to give that person 4 units of Afrezza at each meal, that it is frightening. The worst that could happen to them is that their A1c will only go down to 5.9 in three months, or an average BG of 123.
Spiro here
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Post by spiro on Sept 19, 2015 15:42:32 GMT -5
Compound has got it right. My doctor told me to start with 4 units after every meal, then test my BG at 1, 2 and 3 hours after meals. After 3 days, she wanted to see my BG logs. They were great and I have been at 4 units since day one. It is important to have correction doses for huge carb meals and/or huge snacks.
John still here, Spiro is making a lot of noise watching the Cane game.
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Post by spiro on Sept 19, 2015 14:10:12 GMT -5
thekindaguyiyam,
It's really tough for me to answer all the concerns and comments made by your Endo. I was just an early stage type 2 diabetic with an A1c of 7.1. My doctor and I decided to start treatment with drugs. Afrezza was my choice because of liver and cardiac issues. She agreed to let me try Afrezza. She initially prescribed 4 units at meals for the 1st three months and then added correction doses of 4 units should I eat a big snack ( Cruise ). My A1c dropped to 6.2 after 3 month's. I just had my 6 month blood work taken yesterday. IMO, some doctor's might be overthinking the dosing, particularly for type 2's. I talk with Blindhog quite often, he is going to have an amazing story to share with the board one day. As for the insurance issues, it's a new drug and hopefully Sanofi and MNKD will have this problem resolved soon.
John here, Spiro's watching football on TV
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Post by spiro on Sept 18, 2015 21:40:41 GMT -5
Thanks for the update Zieg. There is a rumor out that Baboriley was the investor being chased all over the MGM Grand by security. Don't believe this picture, Spiro has not been in Las Vegas this week.
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Post by spiro on Sept 16, 2015 16:51:45 GMT -5
Liane,
Spiro wanted to buy more, but at $4.69 a box, the 6 boxes cost Spiro 7.773 shares of MNKD. Good grief that was depressing.
Spiro here, Mallomars taking some of the pain away
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Post by spiro on Sept 16, 2015 16:28:39 GMT -5
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Post by spiro on Sept 13, 2015 11:18:57 GMT -5
OD,
Spiro has never been to an Endo. Spiro's neuropathy pain actually started several month's before his PCP put him on Afrezza. I do not believe that Spiro even mentioned this pain to his PCP.
Spiro here, Neuropathy free and blood glucose under control, thanks to Afrezza.
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Post by spiro on Sept 13, 2015 9:44:40 GMT -5
Do some Endo's really care about their patients? Spiro, since starting Afrezza 6 month's ago, has not had one episode of small fiber neuropathy pain in his hands or feet. Before Afrezza his average BG was 157, now it is around 125. Truthfully, until someone mentioned high blood glucose levels and neuropathy on this board month's ago, Spiro had not connected neuropathy pain to his diabetes. Well, Spiro's Diabetes is still present, but his small fiber neuropathy is damn sure gone. New Research on High Glucose Levels September 12, 2012 by David Spero Print Text Size: A A A American Diabetes Association (ADA) guidelines advise “lowering A1C to below or around 7%” and postprandial (after-meal) glucose levels to 180 mg/dl or below. But new research shows that these glucose levels damage blood vessels, nerves, organs, and beta cells. An article by diabetes blogger Jenny Ruhl analyzes at what blood glucose level organ damage starts. According to Ruhl, research shows that glucose can do harm at much lower levels than doctors had thought. This news could be discouraging or even terrifying. If it’s hard to meet your current glucose goals, how will you reach tighter goals? Such news might make some people give up. But remember, a high postprandial or fasting reading won’t kill you. All we know is that higher numbers correlate with higher chances of complications. You have time to react. In fact, we could choose to look at this as good news. We all know of people who developed complications despite “good control.” But complications are not inevitable; it’s just that so-called “good control” wasn’t really all that good. First, the numbers. “Post-meal blood sugars of 140 mg/dl [milligrams per deciliter] and higher, and fasting blood sugars over 100 mg/dl [can] cause permanent organ damage and cause diabetes to progress,” Ruhl writes.
For nerve damage, University of Utah researchers studied people with painful sensory neuropathy, or nerve damage. They found that participants who did not have diabetes but who had impaired glucose tolerance on an oral glucose tolerance test, or OGTT, (meaning that their glucose levels rose to between 140 mg/dl and 200 mg/dl in response to drinking a glucose-rich drink) were much more likely to have a diabetic form of neuropathy than those with lower blood glucose levels.
The higher these OGTT numbers go, the more nerve damage is found, according to Johns Hopkins Hospital researchers. The OGTT gives a good idea of how high after-meal blood glucose levels are likely to be.
Glucose can also start killing beta cells at levels below 140. One study found that people with fasting blood glucose from 110–125 (within the official “prediabetic” range) had already lost up to 40% of their beta cell mass.
Italian researchers found that even with glucose levels in the supposedly “normal” range, beta cells started to fail. Ruhl says that researchers “found that with every small increase in the 2-hour glucose tolerance test result, there was a corresponding increase in…beta cell failure. The higher a person’s blood sugar rose within ‘normal’ range, the more beta cells were failing.” Failing beta cells will lead to worsening diabetes, a truly vicious cycle. Slightly elevated glucose has also been shown to cause eye damage (“retinopathy”) and increased rates of heart disease, kidney damage, and stroke. Where Does High Start? Studies like the ones Ruhl quotes and others indicate that damage occurs with even slightly elevated blood glucose. But what can you do about that? Is it reasonable to try to keep glucose at normal levels all the time? It seems for some people, that course would lead to frustration and burnout. In fact, ADA says that older, sicker people should have even less strict goals. How do you set reasonable goals for yourself? Keeping normal numbers may require extraordinary effort. It may require very low carbohydrate intake. It may not be possible for you. If you’re taking insulin or drugs in the sulfonylurea or meglitinide classes, aiming too low can put you at risk of hypoglycemia (low blood glucose). The whole thing can make you crazy, because sometimes numbers will go up for no apparent reason. As a result, most people set less-demanding goals for themselves. If they can keep their postprandial glucose under 180 and their fasting below 120, they’re OK, and the ADA agrees. There’s nothing wrong with that. People can trade off how low they want their blood glucose against how much work they are willing to do and how many foods they’re willing to cut back or give up. They are adding to their risk, but, to me, quality of life is the most important thing. Important note: Bringing blood glucose down by means of multiple drugs has NOT been shown to decrease complications much. Two huge studies, the ACCORD and ADVANCE trials showed this. But people who manage to keep normal or near-normal numbers through healthy eating and living and intelligent use of medicines seem to live long, relatively healthy lives. They can even reverse type 2 or the complications of Type 1, even if they have spent years with elevated blood glucose before getting them under control. It’s almost never too late to get on track. So my question is what are your target numbers? How high is too high for you? Does it make sense to aim for normal, non-diabetic levels, or is that just too demanding and unrealistic? If you had a newly diagnosed friend or relative, what would you tell him or her about glucose goals? www.diabetesselfmanagement.com/blog/new-research-on-high-glucose-levels/
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Post by spiro on Sept 12, 2015 18:58:11 GMT -5
Savzak, it's the weekend, Spiro is venting a little. Too many Endo's are happy with an A1c of 8.
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